{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:19:09Z","timestamp":1787894349486,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010457","name":"Centre Hospitalier Universitaire de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Imaging has played a pivotal role in the diagnosis of idiopathic pulmonary fibrosis (IPF). Recent reports suggest that T<jats:sub>2<\/jats:sub>\u2010weighted MRI could be sensitive to monitor signal\u2010intensity modifications of the lung parenchyma, which may relate to the disease activity in IPF. However, there is a lack of automated tools to reproducibly quantify the extent of the disease, especially using MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the feasibility of T<jats:sub>2<\/jats:sub> interstitial lung disease signal\u2010intensity volume quantification using a semiautomated method in IPF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Single center, retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 21 adult IPF patients and four control subjects without lung interstitial abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Both free\u2010breathing ultrashort echo time (TE) lung MRI using the spiral volume interpolated breath hold examination (VIBE) sequence (3D\u2010UTE) and T<jats:sub>2<\/jats:sub>\u2010BLADE at 1.5T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Semiautomated segmentation of the lung volume was done using 3D\u2010UTE and registered to the T<jats:sub>2<\/jats:sub>\u2010BLADE images. The interstitial lung disease signal\u2010intensity volume (ISIV) was quantified using a Gaussian mixture model clustering and then normalized to the lung volume to calculate T<jats:sub>2<\/jats:sub>\u2010ISIV. The composite physiological index (CPI) and forced vital capacity (FVC) were measured as known biomarkers of IPF severity. Measurements were performed independently by three readers and averaged. The reproducibility between measurements was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Reproducibility was assessed using the intraclass correlation coefficient (ICC) and Bland\u2013Altman analysis. Correlations were assessed using Spearman test. Comparison of median was assessed using the Mann\u2013Whitney test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The reproducibility of T<jats:sub>2<\/jats:sub>\u2010ISIV was high, with ICCs = 0.99. Using Bland\u2013Altman analysis, the mean differences were found between \u20130.8 to 0.1. T<jats:sub>2<\/jats:sub>\u2010ISIV significantly correlated with CPI and FVC (rho = 0.48 and 0.50, respectively; <jats:italic>P<\/jats:italic> &lt;\u20090.05). T<jats:sub>2<\/jats:sub>\u2010ISIV was significantly higher in IPF than in controls (<jats:italic>P<\/jats:italic> &lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>T<jats:sub>2<\/jats:sub>\u2010ISIV appears to be able to reproducibly assess the volumetric extent of abnormal interstitial lung signal\u2010intensity modifications in patients with IPF, and correlate with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27454","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T06:41:15Z","timestamp":1606372875000},"page":"1500-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Quantification of <scp>MRI T2<\/scp> Interstitial Lung Disease Signal\u2010Intensity Volume in Idiopathic Pulmonary Fibrosis: A Pilot Study"],"prefix":"10.1002","volume":"53","author":[{"given":"Ilyes","family":"Benlala","sequence":"first","affiliation":[{"name":"Centre de Recherche Cardio\u2010Thoracique de Bordeaux Univ. Bordeaux, INSERM U1045, CIC 1401  Bordeaux France"},{"name":"CHU de Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire Unit\u00e9 de Pneumologie P\u00e9diatrique, CIC 1401  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Albat","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire Unit\u00e9 de Pneumologie P\u00e9diatrique, CIC 1401  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Blanchard","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire Unit\u00e9 de Pneumologie P\u00e9diatrique, CIC 1401  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Macey","sequence":"additional","affiliation":[{"name":"Centre de Recherche Cardio\u2010Thoracique de Bordeaux Univ. 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