{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:40:28Z","timestamp":1764700828178,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011022","name":"Vertex Pharmaceuticals","doi-asserted-by":"publisher","award":["Vertex Innovation Award (VIA) 2017"],"award-info":[{"award-number":["Vertex Innovation Award (VIA) 2017"]}],"id":[{"id":"10.13039\/100011022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>MRI has been suggested as a radiation\u2010free imaging modality to investigate early structural alterations and regional functional impairment in cystic fibrosis (CF) lung disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose\/Hypothesis<\/jats:title><jats:p>To compare functional and morphological MRI changes over the course of the disease to changes in spirometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Longitudinal retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty patients with CF lung disease (at baseline, age = 16.5 (13.3\u201320.6) years, forced expiratory volume in 1\u2009second (as % of predicted [%pred]) FEV<jats:sub>1<\/jats:sub> = 71 (59\u201387) %pred, forced expiratory flow at 25\u201375% of forced vital capacity FEF<jats:sub>25\u201075<\/jats:sub> = 39 (25\u201363) %pred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">1.5T<\/jats:styled-content> \/ <jats:styled-content style=\"fixed-case\">T<jats:sub>2<\/jats:sub><\/jats:styled-content>\u2010weighted HASTE; <jats:styled-content style=\"fixed-case\">T<jats:sub>2<\/jats:sub><\/jats:styled-content>\u2010weighted <jats:styled-content style=\"fixed-case\">TSE\u2010PROPELLER<\/jats:styled-content>; <jats:styled-content style=\"fixed-case\">T<jats:sub>2<\/jats:sub><\/jats:styled-content>\u2010weighted <jats:styled-content style=\"fixed-case\">bSSFP<\/jats:styled-content>; <jats:styled-content style=\"fixed-case\">T<jats:sub>1<\/jats:sub><\/jats:styled-content>\u2010weighted <jats:styled-content style=\"fixed-case\">3D GRE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Nonenhanced chest MRI and spirometry were retrospectively collected over a 3\u2010year period from the initial recruitment visit. Images acquired at end\u2010inspiration and end\u2010expiration were registered by software using the optical flow method to measure expiratory\u2010inspiratory differences in MR signal\u2010intensity (\u0394<jats:sup>1<\/jats:sup>H\u2010MRI). Measures of CF functional impairment were defined from \u0394<jats:sup>1<\/jats:sup>H\u2010MRI: \u0394<jats:sup>1<\/jats:sup>H\u2010MRI median, \u0394<jats:sup>1<\/jats:sup>H\u2010MRI quartile coefficient of variation (QCV), and percent low\u2010signal\u2010variation volume (LVV). MR images were also evaluated by three readers using a CF\u2010specific scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Spearman correlation analysis, Spearman rank correlation analysis, linear mixed\u2010effect model analysis, intraclass correlation coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Functional imaging parameters and total morphological score correlated with all spirometric measures, as did subscores of bronchial wall thickening\/bronchiectasis, mucus plugging, and consolidation. Overall, the percent change of \u03941H\u2010MRI median correlated with the percent change of FEV<jats:sub>1<\/jats:sub> (\u0394FEV<jats:sub>1<\/jats:sub>, <jats:italic>r =<\/jats:italic> 0.41, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and the percent change of FEF<jats:sub>25\u201075<\/jats:sub> (\u0394FEF25\u201075%, <jats:italic>r =<\/jats:italic> 0.38, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The percent change of LVV correlated with \u0394FEV<jats:sub>1<\/jats:sub> (<jats:italic>r =<\/jats:italic> \u20130.47, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and \u0394FEF<jats:sub>25\u201075<\/jats:sub> (<jats:italic>r =<\/jats:italic> \u20130.50, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>These preliminary results suggest that nonenhanced multivolume MRI may provide a feasible tool to regionally map early pulmonary alterations for longitudinal evaluation of CF lung disease, without exposing the patients to ionizing radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3T<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>5<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27461","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:37:05Z","timestamp":1607647025000},"page":"1570-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal Assessment of Patients With Cystic Fibrosis Lung Disease With Multivolume Noncontrast <scp>MRI<\/scp> and Spirometry"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8896-8224","authenticated-orcid":false,"given":"Francesca","family":"Pennati","sequence":"first","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria Politecnico di Milano  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Borzani","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Pediatric Radiology  Milan 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