{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:53:48Z","timestamp":1791233628713,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The fimbria is a small white matter bundle that connects the hippocampus to the rest of the brain. Damage to the hippocampal gray matter is established in Alzheimer's disease (AD), but the hippocampal fimbrial status in the pathogenesis of AD is unclear. AD\u2010related demyelination and iron deposition alter the diamagnetic and paramagnetic composition of tissues, which can be measured by quantitative susceptibility mapping (QSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>AD is associated with microstructural changes in the fimbria that might be detected by QSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study type<\/jats:title>\n                    <jats:p>Retrospective cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>\n                      In all, 53 adults comprised of controls (\n                      <jats:italic>n =<\/jats:italic>\n                      \u00a030), subjects with early stage AD (\n                      <jats:italic>n =<\/jats:italic>\n                      \u00a013), and late stage AD (\n                      <jats:italic>n =<\/jats:italic>\n                      \u00a010) who were classified according to their amyloid and tau status and presence of hippocampal atrophy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength \/ Sequence<\/jats:title>\n                    <jats:p>\n                      3T; 3D fast\u2010field echo sequence for QSM analysis and 3D T\n                      <jats:sub>1<\/jats:sub>\n                      \u2010weighted MP\u2010RAGE sequence for anatomical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>\n                      Segmentation of the left hippocampal fimbria subfield was performed on T\n                      <jats:sub>1<\/jats:sub>\n                      \u2010weighted images and was applied to the coregistered QSM map for extraction of the mean, median, minimum, and maximum values of QSM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical tests<\/jats:title>\n                    <jats:p>Group comparison of QSM values using analysis of variance (ANOVA) with post\u2010hoc Tukey's test, accuracy of binary differentiation using receiver operating characteristic (ROC), and individual classification using discriminant analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      QSM\n                      <jats:sub>mean<\/jats:sub>\n                      and QSM\n                      <jats:sub>median<\/jats:sub>\n                      values were significantly different among the three groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) and showed a shifting from negative in the control group to positive in the AD group. The control and early AD subjects, who have normal hippocampal volumes, were differentiated by the QSM\n                      <jats:sub>mean<\/jats:sub>\n                      value (area under the curve [AUC] 0.744,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) and the QSM\n                      <jats:sub>median<\/jats:sub>\n                      value (AUC 0.782,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Up to 76% of subjects (inclusive of 26 controls and six with early AD) were correctly classified using a model incorporating clinical and radiologic data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>The fimbria showed higher magnetic susceptibility in AD compared with controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy Stage<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.27464","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T09:24:55Z","timestamp":1607592295000},"page":"1823-1832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Quantitative Susceptibility Mapping of the Hippocampal Fimbria in Alzheimer's Disease"],"prefix":"10.1002","volume":"53","author":[{"given":"Chun Ki Franklin","family":"Au","sequence":"first","affiliation":[{"name":"Department of Imaging and Interventional Radiology The Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-709X","authenticated-orcid":false,"given":"Jill","family":"Abrigo","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology The Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8816-4832","authenticated-orcid":false,"given":"Chunlei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Sciences University of California  Berkeley California 94720 USA"},{"name":"Helen Wills Neuroscience Institute University of California  Berkeley California 94720 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Liu","sequence":"additional","affiliation":[{"name":"Gerald Choa Neuroscience Centre, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Division of Neurology, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Trials and Biostatistics Lab CUHK Shenzhen Research Institute  Shenzhen 518063 China"},{"name":"Division of Biostatistics, Jockey Club School of Public Health and Primary Care, Faculty of Medicine The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Wing Chi","family":"Au","sequence":"additional","affiliation":[{"name":"Gerald Choa Neuroscience Centre, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Division of Neurology, Department of Medicine and Therapeutics The Chinese University of Hong Kong, Prince of Wales Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queenie","family":"Chan","sequence":"additional","affiliation":[{"name":"Philips Healthcare  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; 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