{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T07:23:09Z","timestamp":1769930589351,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Potential neurovascular uncoupling (NVU) related to perinidal angiogenesis (PA) of brain arteriovenous malformations (AVMs) may cause inappropriate presurgical mapping using functional magnetic resonance imaging (fMRI), resulting in overconfident resection and postoperative morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the potential impact of PA upon fMRI blood oxygen level\u2010dependent signal in the periphery of AVMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010one patients with AVMs located in the primary sensorimotor cortex (SM1) undergoing task\u2010based fMRI (hand motor), and 19 patients with supratentorial AVMs undergoing resting\u2010state fMRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0T, echo\u2010planar, time\u2010of\u2010flight, and magnetization\u2010prepared rapid gradient\u2010echo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The presence of PA was determined by three observers (Y.C., J.W., and X.C.) according to digital subtraction angiography and MR angiography. Interhemispheric asymmetry of fMRI activations contralateral to hand movements was evaluated with the interhemispheric ratio of the average <jats:italic>t<\/jats:italic>\u2010value within ipsilesional SM1 to contralesional SM1. Regional homogeneity (ReHo) and fractional amplitude of low\u2010frequency fluctuations (fALFF) were extracted from ring\u2010shaped perinidal regions and contralateral homologous regions, and the corresponding interhemispheric ratios were calculated. The effect of PA on the interhemispheric asymmetry of motor activations, ReHo, and fALFF was estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Pearson analysis, paired and independent <jats:italic>t<\/jats:italic>\u2010test, multiple linear regression, Friedman test, and factorial analysis of variance were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Motor activations were significantly reduced in ipsilesional SM1 compared to contralesional SM1 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The presence of PA was the independent predictor of activation loss in ipsilateral SM1(<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, perinidal regions exhibited reduced ReHo compared to the homologous regions (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). PA was significantly associated with the decline of ReHo and fALFF in perinidal regions (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, for both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The presence of PA can predict perinidal NVU that may confound the interpretation of both task\u2010based and resting\u2010state fMRI, highlighting the importance of alternative approaches of brain functional localization in improving treatment of AVMs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27469","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T17:40:50Z","timestamp":1608572450000},"page":"186-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perinidal Angiogenesis Is a Predictor for Neurovascular Uncoupling in the Periphery of Brain Arteriovenous Malformations: A Task\u2010Based and Resting\u2010State <scp>fMRI<\/scp> Study"],"prefix":"10.1002","volume":"54","author":[{"given":"Maogui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"},{"name":"Center of 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