{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:49Z","timestamp":1772118709657,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The safety profiles when performing stress oxygenation\u2010sensitive magnetic resonance imaging (OS\u2010MRI) have raised concerns in clinical practice. Adenosine infusion can cause side effects such as chest pain, dyspnea, arrhythmia, and even cardiac death. The aim of this study was to investigate the feasibility of breathing maneuvers\u2010induced OS\u2010MRI in acute myocardial infarction (MI). This was a prospective study, which included 14 healthy rabbits and nine MI rabbit models. This study used 3\u00a0T MRI\/modified Look\u2010Locker inversion recovery sequence for native T\n                      <jats:sub>1<\/jats:sub>\n                      mapping, balanced steady\u2010state free precession sequence for OS imaging, and phase\u2010sensitive inversion recovery sequence for late gadolinium enhancement. The changes in myocardial oxygenation (\u0394SI) were assessed under two breathing maneuvers protocols in healthy rabbits: a series of extended breath\u2010holding (BH), and a combined maneuver of hyperventilation followed by the extended BH (HVBH). Subsequently, OS\u2010MRI with HVBH in acute MI rabbits was performed, and the \u0394SI was compared with that of adenosine stress protocol. Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, Wilcoxon rank test, and Friedman test were used to compare \u0394SI in different subgroups. Pearson and Spearman correlation was used to obtain the association of \u0394SI between breathing maneuvers and adenosine stress. Bland\u2013Altman analysis was used to assess the bias of \u0394SI between HVBH and adenosine stress. In healthy rabbits, BH maneuvers from 30 to 50\u2009s induced significant increase in SI compared with the baseline (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). By contrast, hyperventilation for 60\u2009s followed by 10\u2009s\u2010BH (HVBH 10\u2009s) exhibited a comparable \u0394SI to that of stress test (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.07). In acute MI rabbits, HVBH 10\u2009s\u2010induced \u0394SIs among infarcted, salvaged, and the remote myocardial area were no less effectiveness than adenosine stress when performing OS\u2010MRI (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.84;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Combined breathing maneuvers with OS\u2010MRI have the potential to be used as a nonpharmacological alternative for assessing myocardial oxygenation in patients with acute MI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy Stage<\/jats:title>\n                    <jats:p>2<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.27509","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T02:47:18Z","timestamp":1610678838000},"page":"284-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Noninvasive oxygenation assessment after acute myocardial infarction with breathing m\n                    <scp>aneuvers\u2010induced<\/scp>\n                    o\n                    <scp>xygenation\u2010sensitive<\/scp>\n                    magnetic resonance imaging"],"prefix":"10.1002","volume":"54","author":[{"given":"Ke","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu Sichuan 610041 China"},{"name":"Department of Radiology State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Chao","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan\u2010Lin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-9887","authenticated-orcid":false,"given":"Ying\u2010Kun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-7697","authenticated-orcid":false,"given":"Zhi\u2010Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University  Chengdu Sichuan 610041 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