{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:46:55Z","timestamp":1776898015130,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Myocardial injury has been found using magnetic resonance imaging in recovered coronavirus disease 2019 (COVID\u201019) patients unselected or with ongoing cardiac symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate for the presence of myocardial involvement in recovered COVID\u201019 patients without cardiovascular symptoms and abnormal serologic markers during hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010one recovered COVID\u201019 patients and 20 healthy controls (HC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0\u2009T, cine, T2\u2010weighted imaging, T1 mapping, and T2 mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Cardiac ventricular function includes end\u2010diastolic volume, end\u2010systolic volume, stroke volume, cardiac output, left ventricle (LV) mass, and ejection fraction (EF) of LV and right ventricle (RV), and segmental myocardial T1 and T2 values were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Student's <jats:italic>t<\/jats:italic>\u2010test, univariate general linear model test, and chi\u2010square test were used for analyses between two groups. Ordinary one\u2010way analyses of variance or Kruskal\u2013Wallis <jats:italic>H<\/jats:italic> test were used for analyses between three groups, followed by post\u2010hoc analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen (71.43%) COVID\u201019 patients had abnormal magnetic resonance findings, including raised myocardial native T1 (5, 23.81%) and T2 values (10, 47.62%), decreased LVEF (1, 4.76%), and RVEF (2, 9.52%). The segmental myocardial T2 value of COVID\u201019 patients (49.20 [46.1, 54.6] msec) was significantly higher than HC (48.3 [45.2, 51.7] msec) (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.001), while the myocardial native T1 value showed no significant difference between COVID\u201019 patients and HC. The myocardial T2 value of serious COVID\u201019 patients (52.5 [48.1, 57.1] msec) was significantly higher than unserious COVID\u201019 patients (48.8 [45.9, 53.8] msec) and HC (48.3 [45.2, 51.7]) (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.001). COVID\u201019 patients with abnormally elevated D\u2010dimer, C\u2010reactive protein, or lymphopenia showed higher myocardial T2 values than without (all <jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Cardiac involvement was observed in recovered COVID\u201019 patients with no preexisting cardiovascular disease, no cardiovascular symptoms, and elevated serologic markers of myocardial injury during the whole course of COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 5<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27534","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T07:27:01Z","timestamp":1613719621000},"page":"421-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cardiac <scp>T1<\/scp> and <scp>T2<\/scp> Mapping Showed Myocardial Involvement in Recovered <scp>COVID<\/scp>\u201019 Patients Initially Considered Devoid of Cardiac Damage"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-888X","authenticated-orcid":false,"given":"Cunxue","family":"Pan","sequence":"first","affiliation":[{"name":"Radiology Department The Fifth Affiliated Hospital of Sun\u2010Yat Sen University  Zhuhai China"},{"name":"Key Laboratory of Biomedical Imaging Fifth Affiliated Hospital of Sun\u2010Yat Sen University  Zhuhai 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