{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:48:28Z","timestamp":1772131708754,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T00:00:00Z","timestamp":1613865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Unilateral middle cerebral artery (MCA) stenosis, as an independent risk factor for stroke, requires an intervention operation for vessel recanalization. Accurate perfusion measurement is thus essential after the operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the feasibility of three\u2010dimensional (3D) pseudo\u2010continuous territorial arterial\u2010spin\u2010labeling (tASL) in evaluating MCA recanalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective and longitudinal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Forty\u2010seven patients with unilateral MCA stenosis or occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A 3.0\u2009T, 3D time\u2010of\u2010flight fast\u2010field\u2010echo magnetic resonance (MR) angiography sequence, spin\u2010echo echo\u2010planar diffusion\u2010weighted imaging sequence, 3D fast\u2010spin\u2010echo pseudo\u2010continuous ASL (pcASL) and tASL sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>All patients underwent MR examination before and after MCA recanalization and scored using the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) at admission and discharge. An mRS score &lt;2 was defined as a good prognosis. 3D\u2010pcASL and tASL cerebral blood flow (CBF) maps were obtained, and the corresponding Alberta Stroke Program Early CT Score (ASPECTS)\u2010based scores were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The Kolmogorov\u2013Smirnov test, intra\u2010class correlation coefficient, paired <jats:italic>t<\/jats:italic>\u2010test, receiver operating characteristic (ROC) curve, and multivariable logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After recanalization, tASL derived absolute CBFs between the affected and contralateral sides were significantly higher than before the operation (mean: 34.3\u2009\u00b1\u20098.5\u2009mL\/100\u2009g\/min vs. 40.6\u2009\u00b1\u20099.2\u2009mL\/100\u2009g\/min, 42.6\u2009\u00b1\u20099.8\u2009mL\/100\u2009g\/min vs. 43.5\u2009\u00b1\u20099.9\u2009mL\/100\u2009g\/min, both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In ROC analysis, tASL provided good prognosis (area under ROC curve [AUC]\u00a0=\u00a00.829; 95% CI: 0.651\u20131.000, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), while pcASL had lower prognostic value (AUC\u00a0=\u00a00.760; 95% CI: 0.574\u20130.946, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The NIHSS score before recanalization, pcASL, and tASL\u2010based ASPECTS scores were significantly associated with good clinical outcome (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariable analysis revealed that ASPECTS\u2010based scores of pcASL and tASL before and after surgery were independent predictors of good clinical outcome (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>tASL can determine hypoperfusion in the responsible vascular perfusion area and predict clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27560","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T03:45:51Z","timestamp":1613965551000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Can <scp>3D<\/scp> Pseudo\u2010Continuous Territorial Arterial Spin Labeling Effectively Diagnose Patients With Recanalization of Unilateral Middle Cerebral Artery Stenosis?"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-3227","authenticated-orcid":false,"given":"Xinyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital)  Jinan Shandong Province 250014 China"},{"name":"Shandong First Medical University  Jinan Shandong Province 250000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqiang","family":"Dou","sequence":"additional","affiliation":[{"name":"MR Research, GE Healthcare  Beijing 10076 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Dong","sequence":"additional","affiliation":[{"name":"Shandong Qianfoshan Hospital, Cheeloo College of Medicine,Shandong University  Jinan Shandong Province 250014 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital)  Jinan Shandong Province 250014 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Shandong First Medical University  Jinan Shandong Province 250000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunjian","family":"Chen","sequence":"additional","affiliation":[{"name":"Shandong First Medical University  Jinan Shandong Province 250000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Mao","sequence":"additional","affiliation":[{"name":"Shandong First Medical University  Jinan Shandong Province 250000 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