{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:06:28Z","timestamp":1753182388008,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671647","81771787"],"award-info":[{"award-number":["81671647","81771787"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Global myocardial strain assessments have been shown to provide useful measures of contractility in many diseases, but whether feature tracking (FT)\u2010derived strain at rest can differentiate ischemic myocardium from infarcted and remote myocardium in patients with coronary artery disease (CAD) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the performance of magnetic resonance imaging FT\u2010derived strain in the detection of regional myocardial deformation in ischemic, infarcted, and apparent normal myocardium in CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 109 patients with CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequences<\/jats:title><jats:p>Steady\u2010state free\u2010precession rest cine, T1\u2010weighted saturation\u2010recovery fast gradient echo stress\/rest perfusion, and two\u2010dimensional phase\u2010sensitive inversion recovery breath\u2010hold late gadolinium enhancement (LGE) tests were performed at 3.0\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Based on perfusion and LGE images, left ventricular (LV) myocardial segments of CAD patients were categorized into ischemic, infarcted, and negative groups. The FT longitudinal (LS) and circumferential strain (CS) of normal subjects and the three CAD groups were calculated. Z\u2010scores of each segment of CAD patients were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistic Tests<\/jats:title><jats:p>\u03c7<jats:sup>2<\/jats:sup> testing, analysis of variance (ANOVA), and Kruskal\u2010Wallis tests. Z\u2010scores were used to compare the strain between CAD groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in global LS (GLS) and CS (GCS) between healthy controls (GLS: \u221219.0%\u2009\u00b1\u20091.4%, GCS, \u221220.9%\u2009\u00b1\u20091.8%), ischemia (GLS: \u221217.4%\u2009\u00b1\u20092.1%, GCS, \u221219.6%\u2009\u00b1\u20091.9%), infarction (GLS: \u221216.4%\u2009\u00b1\u20091.9%, GCS, \u221217.8%\u2009\u00b1\u20091.9%), and negative patients (GLS: \u221217.7%\u2009\u00b1\u20091.4%, GCS, \u221220.9%\u2009\u00b1\u20092.4%) (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). There were significant differences in regional LS and CS between ischemic (LS, \u221216.1%\u2009\u00b1\u20095.0%, CS, \u221218.7%\u2009\u00b1\u20095.0%), infarcted (LS, \u221214.8%\u2009\u00b1\u20095.2%, CS, \u221215.3%\u2009\u00b1\u20094.8%), and negative segments (LS, \u221217.6%\u2009\u00b1\u20095.2%, CS, \u221219.8%\u2009\u00b1\u20094.8%) (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The differences in the z\u2010scores of regional LS and CS between the ischemic, infarcted, and negative segments were also significant (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>FT\u2010derived rest strain indices of the LV myocardium of CAD patients were higher compared to healthy controls and varied between ischemic, infarcted, and negative segments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 5.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27588","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T05:50:05Z","timestamp":1614923405000},"page":"808-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Myocardial Deformation Assessed by <scp>MR<\/scp> Feature Tracking in Groups of Patients With Ischemic Heart Disease"],"prefix":"10.1002","volume":"54","author":[{"given":"Lei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"DeLano","sequence":"additional","affiliation":[{"name":"Spectrum Health System, Advanced Radiology Services PC, Division of Radiology and Biomedical Imaging, College of Human Medicine Michigan State University  Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-0119","authenticated-orcid":false,"given":"Xiaohai","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Interventional Diagnosis and Therapy, Beijing Anzhen Hospital Capital Medical University  Beijing 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