{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:04:30Z","timestamp":1792638270153,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14GRNT20150004"],"award-info":[{"award-number":["14GRNT20150004"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19CDA34790002"],"award-info":[{"award-number":["19CDA34790002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R01NS097763"],"award-info":[{"award-number":["1R01NS097763"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["5R01NS078828"],"award-info":[{"award-number":["5R01NS078828"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,9]]},"abstract":"\n Background<\/jats:title>\n Patients with symptomatic atherosclerotic and non\u2010atherosclerotic (i.e., moyamoya) intracranial steno\u2010occlusive disease experience high 2\u2010year infarct rates.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To investigate whether cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) measures may provide biomarkers of 1\u2010to\u20102\u2010year infarct risk.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective, longitudinal study.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n \n Adult participants (age\u00a0=\u00a018\u201385\u2009years) with symptomatic intracranial atherosclerotic disease (\n N<\/jats:italic>\n \u00a0=\u00a026) or non\u2010atherosclerotic (i.e., moyamoya;\n N<\/jats:italic>\n \u00a0=\u00a043) and stenosis \u226550% of a major intracranial artery were initially scanned within 45\u2009days of stroke. Follow\u2010up imaging (target \u00a0=\u00a01.5\u2009years) was acquired for new infarct assessment.\n <\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n \n 3.0 Tesla with normocapnic arterial spin labeling (\n ASL<\/jats:styled-content>\n ) and blood oxygenation level\u2010dependent (\n BOLD<\/jats:styled-content>\n ) imaging acquired during an interleaved hypercapnic (3\u2009minutes) and normocapnic (3\u2009minutes) respiratory stimulus.\n <\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n \n CBF, maximum CVR, and time\u2010to\u2010maximum CVR (i.e., CVR\n DELAY<\/jats:sub>\n ) were calculated. Laterality indices (difference between infarcted and contralesional hemispheres divided by sum of absolute values) of metrics at enrollment were contrasted between participants with vs. without new infarcts on follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Laterality indices were compared using non\u2010parametric Wilcoxon tests (significance: two\u2010sided\n P<\/jats:italic>\n \u2009<\u20090.05) and effect sizes as Cohen's\n d<\/jats:italic>\n . Continuous variables are presented as mean\u2009\u00b1\u2009SD.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n New infarcts were observed on follow\u2010up in 15.0% of participants. The laterality index of the CVR\n DELAY<\/jats:sub>\n was elevated (\n P<\/jats:italic>\n \u00a0=\u00a00.01) in participants with atherosclerosis with new infarcts (index\u00a0=\u00a00.13) compared to participants without new infarcts (index\u00a0=\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n \n Elevated CVR\n DELAY<\/jats:sub>\n may indicate brain parenchyma at increased risk for new infarcts in patients with symptomatic intracranial atherosclerotic disease treated with standard\u2010of\u2010care medical management.\n <\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 2<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy Stage<\/jats:title>\n 3<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.27605","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T01:58:12Z","timestamp":1616637492000},"page":"912-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Prospective, Longitudinal\n Magnetic Resonance Imaging<\/scp>\n Evaluation of Cerebrovascular Reactivity and Infarct Development in Patients With Intracranial Stenosis"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-3648","authenticated-orcid":false,"given":"Meher R.","family":"Juttukonda","sequence":"first","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Charlestown Massachusetts USA"},{"name":"Department of Radiology Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry T.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Lants","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer L.","family":"Waddle","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niral J.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori C.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Pediatrics, Division of Pediatric Neurology Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Neurology Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manus J.","family":"Donahue","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Neurology Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"issue":"12","key":"e_1_2_6_2_1","first-page":"412","article-title":"Intracranial atherosclerotic disease: Epidemiology, imaging and treatment","volume":"92","author":"McTaggart RA","year":"2009","journal-title":"Med Health R I"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62038-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.4.JNS081649"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000229"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.3.JNS08837"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70240-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17732884"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24070"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17721830"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf047"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17700913"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16682509"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx635"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25197"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15608643"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.09.007"},{"issue":"5","key":"e_1_2_6_21_1","first-page":"1012","article-title":"Intracranial vascular stenosis and occlusive disease: Evaluation with CT angiography, MR angiography, and digital subtraction angiography","volume":"26","author":"Bash S","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043033"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.7.1187"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.015"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.194"},{"key":"e_1_2_6_26_1","first-page":"230","article-title":"Characterizing cerebral hemodynamics across the adult lifespan with arterial spin labeling MRI data from the Human Connectome Project\u2013Aging","volume":"117807","author":"Juttukonda MR","year":"2021","journal-title":"Neuroimage"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021184"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4315"},{"key":"e_1_2_6_29_1","first-page":"STROKEAHA118020","article-title":"Hemodynamic markers in the anterior circulation as predictors of recurrent stroke in patients with intracranial stenosis","author":"Wabnitz AM","year":"2018","journal-title":"Stroke"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.7.1347"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014538"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015141865"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2019.03.003"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1922"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19848098"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348841"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.106"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005975"},{"issue":"12","key":"e_1_2_6_39_1","first-page":"2906","article-title":"Effects of oxygen and carbogen breathing on choroidal hemodynamics in humans","volume":"40","author":"Kergoat H","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.168"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24175"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.27605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:14:17Z","timestamp":1693228457000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.27605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/jmri.27605"],"URL":"https:\/\/doi.org\/10.1002\/jmri.27605","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,24]]},"assertion":[{"value":"2020-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}