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Visual and quantitative analysis of MRI data was compared to QCA. Quantitative analysis assessed average myocardial perfusion reserve (MPR), average stress myocardial blood flow (MBF), and lowest stress MBF of two contiguous myocardial segments. Ischemic burden was measured visually and quantitatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Student's t\u2010test, McNemar's test, chi\u2010square statistic, linear mixed\u2010effects model, and area under receiver\u2010operating characteristic curve (ROC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Per\u2010patient visual analysis demonstrated a sensitivity of 84% (95% confidence interval [CI], 60%\u201397%) and specificity of 83% [95% CI, 36%\u2013100%]. There was no significant difference between per\u2010vessel visual and quantitative analysis for sensitivity (69% [95% CI, 51%\u201384%] vs. 77% [95% CI, 60%\u201390%], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.39) and specificity (88% [95% CI, 73%\u201396%] vs. 80% [95% CI, 64%\u201391%], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.75). Per\u2010vessel quantitative analysis ROC showed no significant difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) between average MPR (0.68 [95% CI, 0.56\u20130.81]), average stress MBF (0.74 [95% CI, 0.63\u20130.86]), and lowest stress MBF (0.79 [95% CI, 0.69\u20130.90]). Visual and quantitative ischemic burden measurements were comparable (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.85).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Whole\u2010heart VDS stress perfusion demonstrated good diagnostic accuracy and ischemic burden evaluation. No significant difference was seen between visual and quantitative diagnostic performance and ischemic burden measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27620","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T12:11:11Z","timestamp":1617711071000},"page":"1268-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Accuracy of Spiral <scp>Whole\u2010Heart<\/scp> Quantitative Adenosine Stress Cardiovascular Magnetic Resonance With Motion Compensated <scp>L1\u2010SPIRIT<\/scp>"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5938-4799","authenticated-orcid":false,"given":"Jonathan 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Department of Medicine University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"McHugh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric M.","family":"Holland","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig H.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging University of Virginia Health System  Charlottesville Virginia USA"},{"name":"Department of Biomedical Engineering University of Virginia  Charlottesville Virginia 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