{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:39:17Z","timestamp":1774327157461,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["R01 HL131975"],"award-info":[{"award-number":["R01 HL131975"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1650604"],"award-info":[{"award-number":["1650604"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical management of boys with Duchenne muscular dystrophy (DMD) relies on in\u2010depth understanding of cardiac involvement, but right ventricular (RV) structural and functional remodeling remains understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate several analysis methods and identify the most reliable one to measure RV pre\u2010 and postcontrast T1 (RV\u2010T1) and to characterize myocardial remodeling in the RV of boys with DMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Boys with DMD (<jats:italic>N<\/jats:italic>\u00a0=\u00a027) and age\u2010\/sex\u2010matched healthy controls (<jats:italic>N<\/jats:italic>\u00a0=\u00a017) from two sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0\u2009T using balanced steady state free precession, motion\u2010corrected phase sensitive inversion recovery and modified Look\u2010Locker inversion recovery sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Biventricular mass (Mi), end\u2010diastolic volume (EDVi) and ejection fraction (EF) assessment, tricuspid annular excursion (TAE), late gadolinium enhancement (LGE), pre\u2010 and postcontrast myocardial T1 maps. The RV\u2010T1 reliability was assessed by three observers in four different RV regions of interest (ROI) using intraclass correlation (ICC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The Wilcoxon rank sum test was used to compare RV\u2010T1 differences between DMD boys with negative LGE(\u2212) or positive LGE(+) and healthy controls. Additionally, correlation of precontrast RV\u2010T1 with functional measures was performed. A <jats:italic>P<\/jats:italic>\u2010value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 1\u2010pixel thick RV circumferential ROI proved most reliable (ICC\u2009&gt;\u20090.91) for assessing RV\u2010T1. Precontrast RV\u2010T1 was significantly higher in boys with DMD compared to controls. Both LGE(\u2212) and LGE(+) boys had significantly elevated precontrast RV\u2010T1 compared to controls (1543 [1489\u20131597] msec and 1550 [1402\u20131699] msec vs. 1436 [1399\u20131473] msec, respectively). Compared to healthy controls, boys with DMD had preserved RVEF (51.8 [9.9]% vs. 54.2 [7.2]%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.31) and significantly reduced RVMi (29.8 [9.7]\u00a0g vs. 48.0 [15.7]\u00a0g), RVEDVi (69.8 [29.7]\u00a0mL\/m<jats:sup>2<\/jats:sup> vs. 89.1 [21.9]\u00a0mL\/m<jats:sup>2<\/jats:sup>), and TAE (22.0 [3.2]\u00a0cm vs. 26.0 [4.7]\u00a0cm). Significant correlations were found between precontrast RV\u2010T1 and RVEF (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.48%\/msec) and between LV\u2010T1 and LVEF (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.51%\/msec).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Precontrast RV\u2010T1 is elevated in boys with DMD compared to healthy controls and is negatively correlated with RVEF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27729","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T09:52:05Z","timestamp":1622022725000},"page":"1503-1513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Right Ventricular Function and <scp>T1<\/scp>\u2010Mapping in Boys With Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-8270","authenticated-orcid":false,"given":"Seraina A.","family":"Dual","sequence":"first","affiliation":[{"name":"Department of Radiology Stanford University  Palo Alto California USA"},{"name":"Department of Cardiothoracic Surgery Stanford University  Palo Alto California USA"},{"name":"Cardiovascular Institute Stanford University  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5741-7021","authenticated-orcid":false,"given":"Nyasha G.","family":"Maforo","sequence":"additional","affiliation":[{"name":"Physics and Biology in Medicine Interdepartmental Program University of California  Los Angeles California USA"},{"name":"Department of Radiological Sciences University of California  Los Angeles California 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