{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:41:26Z","timestamp":1787316086392,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fetal growth restriction (FGR) is associated with a high fetal brain volume\/liver volume (FBV\/FLV) ratio. Ultrasound may not always be reliable, which has prompted further investigation of MRI techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the relationship between FBV\/FLV ratio, as measured by MRI, and gestational age (GA) in normal fetuses and those with FGR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>One hundred and forty seven singleton pregnancies including 105 appropriate\u2010for\u2010gestational age (AGA) fetuses and 42 FGR fetuses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>Three\u2010dimensional fast imaging employing steady\u2010state acquisition at 1.5\u2009T.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>The FBV and FLV were measured by three radiologists. The inter\u2010 and intraobserver agreements, the correlation between FBV\/FLV ratio, and advancing GA were evaluated; the diagnostic value of FBV\/FLV ratio was evaluated and compared with head circumference\/abdominal circumference (HC\/AC) ratio measured by ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>Intraclass correlation coefficient (ICC) was used to determine inter\u2010 and intraobserver agreements. Regression analysis was used to assess the correlation between FBV\/FLV ratio and advancing GA. The diagnostic value of the FBV\/FLV ratio was examined by the area under the receiver operating characteristic (ROC) curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The inter\u2010 and intraobserver agreements were excellent with an interobserver ICC of 0.984 and intra\u2010observer ICCs of 0.989, 0.994, and 0.995. The FBV\/FLV ratio in AGA fetuses decreased significantly with advancing GA (Pearson correlation coefficient\u00a0=\u00a0\u22120.844). The FBV\/FLV ratio in FGR fetuses was significantly higher than that in AGA fetuses. To identify fetuses at high risk for FGR using the FBV\/FLV ratio, the area under the ROC curve was 0.978, with an optimal cut\u2010off value of 4.10. The sensitivity of FBV\/FLV ratio in identifying FGR was significantly higher than that of HC\/AC ratio (0.929 vs. 0.529).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>An inverse correlation exists between FBV\/FLV ratio and advancing GA in normal fetuses. A high FBV\/FLV ratio may be used to ascertain fetuses at high risk for FGR.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Level of Evidence<\/jats:bold>\n                      : 3\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Technical Efficacy Stage<\/jats:bold>\n                      : 3\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.27792","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T23:31:17Z","timestamp":1624318277000},"page":"1796-1801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Measurement of the Brain Volume\/Liver Volume Ratio by Three\u2010Dimensional\n                    <scp>MRI<\/scp>\n                    in Appropriate\u2010for\u2010Gestational Age Fetuses and Those With Fetal Growth Restriction"],"prefix":"10.1002","volume":"54","author":[{"given":"Kui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Women's Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Women's Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-1496","authenticated-orcid":false,"given":"Weizeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Women's Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology, Women's Hospital Zhejiang University School of Medicine  Hangzhou 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