{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:25:18Z","timestamp":1758637518792,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diffusion weighted imaging (DWI) is fundamental for prostate cancer (PCa) detection with MRI; however, limited by susceptibility artifact from hip prosthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate image quality and ability to detect PCa with quantitative T2\u2010mapping and DWI in men with hip prosthesis undergoing prostate MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective, cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Thirty consecutive men with hip replacement (18 unilateral, 12 bilateral) undergoing prostate MRI from 2019 to 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2010T; multiparametric MRI (T2W, DCE\u2010MRI, echo\u2010planar [EPI]\u2010DWI), T2\u2010mapping (Carr\u2010Purcell\u2010Meiboom\u2010Gill), FOCUS\u2010EPI\u2010DWI, PROPELLER\u2010DWI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Five blinded radiologists independently evaluated MRI image quality using a 5\u2010point Likert scale. PI\u2010RADS v2.1 scores were applied in four interpretation strategies: 1) T2W\u2010FSE+DCE\u2010MRI+EPI\u2010DWI, 2) T2W\u2010FSE+DCE\u2010MRI+EPI\u2010DWI+FOCUS\u2010EPI\u2010DWI, 3) T2W\u2010FSE+DCE\u2010MRI+EPI\u2010DWI+PROPELLER\u2010DWI, 4) T2W\u2010FSE+DCE\u2010MRI+EPI\u2010DWI+T2\u2010maps. Five\u2010point confidence scores were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Analysis<\/jats:title><jats:p>ANOVA, Kruskal\u2013Wallis with pair\u2010wise comparisons by Wilcoxon sign\u2010rank, and paired <jats:italic>t<\/jats:italic>\u2010tests, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered significant. Cohen's Kappa (<jats:italic>k<\/jats:italic>) for PI\u2010RADSv2.1 scoring and proportion of correctly classified lesions tabulated for pathology\u2010confirmed cases with 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all radiologists, T2\u2010map image quality was significantly higher than EPI\u2010DWI, FOCUS\u2010EPI\u2010DWI, and PROPELLER\u2010DWI and similar (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.146\u20130.706) or significantly better (for two readers) than T2W\u2010FSE and DCE\u2010MRI.<\/jats:p><jats:p>PI\u2010RADS v2.1 agreement improved comparing strategy A (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.46) to strategy B (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.58) to strategy C (<jats:italic>k<\/jats:italic>\u00a0=\u00a00.58) and was highest with strategy D which included T2\u2010maps (<jats:italic>k<\/jats:italic>\u00a0=\u00a01.00). Radiologists' confidence was significantly highest with strategy D. Strategies B and C had similar confidence (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.051\u20130.063) both significantly outperforming strategy A.<\/jats:p><jats:p>Twelve men with 17 lesions had pathology confirmed diagnoses (13 PCa, 4 benign). Strategy D had the highest proportion of correctly classified lesions (76.5\u201382.4%) with overlapping 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>T2\u2010mapping may be a valuable adjunct to prostate MRI in men with hip replacement resulting in improved image quality, higher reader confidence, interobserver agreement, and accuracy in PI\u2010RADS scoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27803","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T09:28:10Z","timestamp":1625477290000},"page":"265-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Utility of Quantitative <scp>T2<\/scp>\u2010Mapping Compared to Conventional and Advanced Diffusion Weighted Imaging Techniques for Multiparametric Prostate <scp>MRI<\/scp> in Men with Hip Prosthesis"],"prefix":"10.1002","volume":"55","author":[{"given":"Paul","family":"Sathiadoss","sequence":"first","affiliation":[{"name":"Department of Medical Imaging The Ottawa Hospital, University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-4786","authenticated-orcid":false,"given":"Nicola","family":"Schieda","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging The Ottawa Hospital, University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Haroon","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging The Ottawa Hospital, University of Ottawa  Ottawa Ontario 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