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However, the interhemispheric coordination of T2DM patients is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate interhemispheric functional and anatomic connectivity in T2DM, and their associations with cognitive performance and endocrine parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>38 <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content> patients and 42 matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequences<\/jats:title><jats:p>3.0\u2009T magnetic resonance imaging (MRI) scanner; magnetization\u2010prepared rapid acquisition gradient echo sequence; fluid\u2010attenuated inversion recovery sequence; single\u2010shot, gradient\u2010recalled echo\u2010planar imaging sequence (resting\u2010state functional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>); and diffusion\u2010weighted spin\u2010echo\u2010based echo\u2010planar sequence (diffusion tensor imaging).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Voxel\u2010mirrored homotopic connectivity (VMHC) value was calculated based on the functional images. Fibers passing through the regions with significant VMHC differences were identified using an atlas\u2010guided track recognition. The mean fractional anisotropy (FA), mean diffusivity (MD), and fiber length were extracted and compared between the two groups. Finally, correlational analyses were performed to examine the relationships between abnormal interhemispheric connectivity, cognitive performances, and endocrine parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Two\u2010sample <jats:italic>t<\/jats:italic>\u2010tests were performed controlling for confounding factors, with partial correlation analysis. False discovery rate (FDR) correction was used for multiple comparisons. A <jats:italic>P<\/jats:italic> value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T2DM patients exhibited significantly decreased VMHC between bilateral lingual gyrus and sensorimotor cortex. The fibers connecting lingual gyrus in patients showed significantly lower FA (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) and shorter fiber length (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), while the differences in sensorimotor fibers were insignificant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.096 for FA, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.739 for fiber length and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.150 for MD). The FA value in the lingual fibers was negatively correlated with insulin resistance (IR) level in T2DM group after FDR correction (<jats:italic>R<\/jats:italic>\u00a0=\u00a0\u22120.635).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>We noted disruptions in interhemispheric coordination in T2DM patients, involving both functional and anatomical connectivities. IR might be a promising therapeutic target in the intervention of T2DM\u2010related cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27813","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T06:54:55Z","timestamp":1624949695000},"page":"424-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Disturbed Interhemispheric Functional and Structural Connectivity in Type 2 Diabetes"],"prefix":"10.1002","volume":"55","author":[{"given":"Ying","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Radiology, Zhongda Hospital, School of Medicine Southeast University  Nanjing 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