{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:42:49Z","timestamp":1781332969241,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001762"],"award-info":[{"award-number":["82001762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>T1, T2, and T1\u03c1 might be potential biomarkers for assessing liver fibrosis. However, few studies reported the value of them in different animal models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate and compare the performances of T1, T2, and T1\u03c1 for noninvasively staging liver fibrosis in bile duct ligation (BDL) or carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Liver fibrosis was induced by BDL or injection of CCl<jats:sub>4<\/jats:sub> in 120 rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>11.7\u00a0T, T1 mapping with 10 repetition times, T2 mapping with 32 echo times, and T1\u03c1 with 10 spin\u2010lock times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>T1, T2, and T1\u03c1 were measured and correlated with liver fibrosis stages, as well as the degree of inflammation, steatosis, iron deposition, and the expression of cytokeratin 19. The discriminative performance of T1, T2, and T1\u03c1 for staging liver fibrosis was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>One\u2010way analysis of variance (ANOVA), Spearman's correlation analysis, factorial design ANOVA, and receiver operating characteristic curves (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T1, T2, and T1\u03c1 (BDL: rho\u00a0=\u00a00.73, 0.85, 0.68; CCl<jats:sub>4<\/jats:sub>: rho\u00a0=\u00a00.80, 0.29, 0.61) were significantly correlated with liver fibrosis stages, while there was no significant difference in T2 among stage F0\u2013F4 in the CCl<jats:sub>4<\/jats:sub> model (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.204). The area under the curves (AUCs) range of T1, T2, and T1\u03c1 for predicting \u2265F1, \u2265F2, \u2265F3, and F4 were 0.76\u20130.95, 0.89\u20130.98, and 0.80\u20130.94 in the CCl<jats:sub>4<\/jats:sub> model. For the CCl<jats:sub>4<\/jats:sub> model, the AUCs range of T1, T2, and T1\u03c1 for predicting \u2265F1, \u2265F2, \u2265F3, and F4 were 0.83\u20130.95, 0.61\u20130.74, and 0.73\u20130.89, respectively. T2 had significantly higher AUC in the BDL model than CCl<jats:sub>4<\/jats:sub> model for diagnosing liver fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The most sensitive and accurate method for staging liver fibrosis appeared to be T1 in our animal models followed by T1\u03c1. T2 may not be suitable for evaluating liver fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27822","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T07:24:05Z","timestamp":1626161045000},"page":"507-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Staging Liver Fibrosis: Comparison of Native <scp>T1<\/scp> Mapping, <scp>T2<\/scp> Mapping, and T1\u03c1: An Experimental Study in Rats With Bile Duct Ligation and Carbon Tetrachloride at 11.<scp>7\u00a0T MRI<\/scp>"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-910X","authenticated-orcid":false,"given":"Yimei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Radiology, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiwu","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.09.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111423"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2017.04.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.084"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06038.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25550"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019190034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172765"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29302"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100067"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314561"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02822-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180051"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-019-0100-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2378-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2016.03.02"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(90)90137-Q"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23606"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101638"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2016.08.11"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199905000-00006"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06335-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26995"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.024"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1286057"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-012-9337-x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.02.004"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.128"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020192118"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25424"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30150"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6050"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3299"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4284"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.27822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.27822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T12:15:45Z","timestamp":1692879345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.27822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,13]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/jmri.27822"],"URL":"https:\/\/doi.org\/10.1002\/jmri.27822","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,13]]},"assertion":[{"value":"2021-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}