{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:52:33Z","timestamp":1791197553903,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>3.0\u2009T non\u2010contrast\u2010enhanced nitroglycerin (<jats:styled-content style=\"fixed-case\">NTG<\/jats:styled-content>)\u2010assisted whole\u2010heart coronary <jats:styled-content style=\"fixed-case\">magnetic resonance<\/jats:styled-content> angiography (<jats:styled-content style=\"fixed-case\">MRA<\/jats:styled-content>) employing Dixon water\u2010fat separation and compressed <jats:styled-content style=\"fixed-case\">SENSE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CS\u2010SENSE<\/jats:styled-content>) acceleration is a promising method for diagnosing coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the diagnostic performance of this technique for detecting clinically\u2010relevant (\u226550% diameter reducing) CAD and to evaluate the difference in NTG\u2010induced coronary vasodilation between patients with and without clinically\u2010relevant CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Sixty\u2010six patients with suspected CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0\u00a0T; <jats:styled-content style=\"fixed-case\">CSSENSE<\/jats:styled-content>, Dixon water\u2010fat separation, three\u2010dimensional segmented turbo field gradient\u2010echo sequence for whole\u2010heart <jats:styled-content style=\"fixed-case\">coronary MRA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Overall image quality of coronary MRA was calculated on the basis of all visible coronary segments. The diagnostic performance of coronary MRA for detecting a \u226550% reduction in coronary artery diameter with and without NTG was compared using X\u2010ray coronary angiography (CAG) as the reference. According to CAG, patients were divided into a non\u2010clinically\u2010relevant CAD group and clinically\u2010relevant CAD group, and the difference in NTG\u2010induced vasodilation between the groups was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Unpaired\/paired Student's <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, paired Wilcoxon signed\u2010rank test, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test, McNemar test. A two\u2010tailed <jats:italic>P<\/jats:italic> value &lt;0.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall image quality was increased significantly in the coronary MRA images after NTG. The diagnostic performance of the non\u2010NTG vs. NTG\u2010assisted coronary MRA was as follows on a per\u2010patient basis: sensitivity 94.3% vs. 94.3%, specificity 64.5% vs. 83.9%, positive predictive value 75.0% vs. 86.8%, negative predictive value 90.9% vs. 92.9%, and accuracy 80.3% vs. 89.4%, respectively. NTG\u2010induced vasodilation was significantly lower in the clinically\u2010relevant CAD group than in the non\u2010clinically\u2010relevant CAD group (13.7\u2009\u00b1\u20098.1% vs. 24.1\u2009\u00b1\u200916.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Non\u2010contrast Dixon water\u2010fat separation CS\u2010SENSE coronary MRA at 3.0\u00a0T can noninvasively detect clinically\u2010relevant CAD and sublingual NTG improved performance. Combining pre\u2010 and post\u2010NTG coronary MRA may provide a simple noninvasive and nonionizing test to evaluate coronary vasodilation function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27829","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T07:07:37Z","timestamp":1626160057000},"page":"579-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical Application of Non\u2010Contrast\u2010Enhanced Dixon Water\u2010Fat Separation Compressed <scp>SENSE<\/scp> Whole\u2010Heart Coronary <scp>MR<\/scp> Angiography at 3.0\u00a0T With and Without Nitroglycerin"],"prefix":"10.1002","volume":"55","author":[{"given":"Hongfei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Radiology 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