{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:11:28Z","timestamp":1787793088199,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The pathophysiology of rigidity in Parkinson's disease (PD) is poorly understood. Multi\u2010sequence functional and structural brain MRI may further clarify the origin of this clinical characteristic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine both joint and unique relationships of MRI\u2010based functional and structural imaging modalities to rigidity and other clinical features of PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>31 <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> subjects (aged 68.0\u2009\u00b1\u20095.9\u2009years, 21 males) with average disease duration 9.3\u2009\u00b1\u20095.4\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Multi\u2010echo GRASE, diffusion\u2010weighted echo planar imaging (EPI), and blood oxygen level dependent contrast EPI T2*\u2010weighted sequences on a 3T scanner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Myelin water fraction (MWF) and fractional anisotropy (FA) of 20 white\u2010matter regions of interest (ROIs), and functional connectivity derived from resting\u2010state fMRI among 56 ROIs were assessed. The Unified Parkinson's Disease Rating Scale\u2014Part III, Montreal Cognitive Assessment, Beck Depression Index, and Apathy Rating Scales were used to assess motor and non\u2010motor symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Multiset canonical correlation analysis (MCCA) and canonical correlation analysis (CCA) were utilized to examine the joint and unique relationships of multiple imaging measures with clinical symptoms of PD. A permutation test was used to determine statistical significance (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MCCA revealed a single significant component jointly linking MWF, FA, and functional connectivity to age, bradykinesia, and leg agility, non\u2010motor symptoms of cognition, depression, and apathy, but not rigidity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.77), tremor (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.50 and 0.67 on the left and right side), or sex (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.54). After controlling for this joint component, CCA found a unique significant association between MWF and rigidity, but no other associations were detected, including with FA (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>MWF, FA, and functional connectivity can serve as multi\u2010sequence imaging markers to characterize many PD symptoms. However, rigidity in PD is additionally associated with widespread myelin changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27853","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T04:12:13Z","timestamp":1628568733000},"page":"451-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Multi\u2010sequence <scp>MRI<\/scp> Study in Parkinson's Disease: Association Between Rigidity and Myelin"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2984-500X","authenticated-orcid":false,"given":"Jiayue","family":"Cai","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Health Science Center Shenzhen University  Shenzhen China"},{"name":"Department of Medicine, Division of Neurology The University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jowon L.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology The University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias R.","family":"Baumeister","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering The University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Neurology The University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Wang","sequence":"additional","affiliation":[{"name":"School 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