{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:43Z","timestamp":1791489703958,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,3]]},"abstract":"\n Background<\/jats:title>\n Pediatric inflammatory multisystem syndrome temporally associated with SARS\u2010CoV\u20102 (PIMS\u2010TS) is an inflammatory disease occurring in a small minority of children a few weeks after acute infection. Cardiac manifestations are common, but little is known about the potentially persistent heart changes after PIMS\u2010TS.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To analyze the frequency and type of myocardial complications of PIMS\u2010TS with initial cardiac involvement assessed with cardiac magnetic resonance imaging (MRI), including parametric imaging, performed 3\u2009months after hospitalization.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Nineteen consecutive children (median age 10\u2009years, interquartile range (IQR) 10\u201315\u2009years, 74% male).<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n Balanced steady state free precession (bSSFP, cine imaging), modified Look\u2010Locker (T1 mapping), T2\u2010prepared bSSFP (T2\u2010mapping), dark\u2010blood T2\u2010weighted turbo spin echo with fat suppression and phase sensitive inversion recovery (late gadolinium enhancement (LGE)) sequences at 1.5\u2009T.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Patients were scanned after a median of 99\u2009days (IQR 89\u2013104\u2009days) from the diagnosis. MR data were reviewed by three independent observers, with 13, 2, and 5\u2009years' experience in cardiac MRI. Pre\u2010 and post\u2010contrast T1, T2, extra\u2010cellular volume, and T2 signal intensity (T2 SI) ratio were calculated. Diagnosis of acute myocarditis was based on modified Lake Louise criteria. Cardiac MRI parameters were compared, where possible, to previously published pediatric normal values.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Interclass correlation coefficient and Bland\u2013Altman repeatability analysis. A\n P<\/jats:italic>\n \u2010value <0.05 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Despite cardiac involvement including decreased left ventricular ejection fraction (LVEF) (median LVEF\u00a0=\u00a047%, IQR 43%\u201353%) and increased troponin I (median 101\u2009ng\/mL, IQR 50\u2013661\u2009ng\/mL) during hospitalization, there were no persistent cardiac changes observed in cardiac MR at follow\u2010up. All patients had normal size and function of the left ventricle and normal precontrast T1 and T2 relaxation times. There were no signs of LGE. Persistent, mild pericardial effusion (8\u20139\u2009mm) was found in three (16%) patients.<\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n There were no persistent changes on cardiac MRI in a group of children approximately 3\u2009months post hospitalization due to PIMS\u2010TS with cardiac involvement. This supports the hypothesis that cardiac involvement during PIMS\u2010TS is a form of transient inflammatory response rather than direct and potentially persistent injury from the virus.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 4<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 3<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.27870","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T02:45:46Z","timestamp":1627613146000},"page":"883-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cardiac Magnetic Resonance Follow\u2010Up of Children After Pediatric Inflammatory Multisystem Syndrome Temporally Associated With\n SARS\u2010CoV<\/scp>\n \u20102 With Initial Cardiac Involvement"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-8371","authenticated-orcid":false,"given":"Marta","family":"Bartoszek","sequence":"first","affiliation":[{"name":"Department of Pediatric Radiology Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-0163","authenticated-orcid":false,"given":"\u0141ukasz A.","family":"Ma\u0142ek","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion National Institute of Cardiology Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-7302","authenticated-orcid":false,"given":"Marzena","family":"Barczuk\u2010Fal\u0119cka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3453-1013","authenticated-orcid":false,"given":"Micha\u0142","family":"Brzewski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049836"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100527"},{"key":"e_1_2_6_4_1","unstructured":"World Health Organization. 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