{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:19:43Z","timestamp":1791523183929,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7204327"],"award-info":[{"award-number":["7204327"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["Z190020"],"award-info":[{"award-number":["Z190020"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diffusion\u2010weighted imaging (DWI) can quantify the microstructural changes in the spinal cord. It might be a substitute for T2 increased signal intensity (ISI) for cervical spondylotic myelopathy (CSM) evaluation and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the study is to investigate the relationship between DWI metrics and neurologic function of patients with CSM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Forty\u2010eight patients with CSM (18.8% females) and 36 healthy controls (HCs, 25.0% females).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2009T; spin\u2010echo echo\u2010planar imaging\u2010DWI; turbo spin\u2010echo T1\/T2; multi\u2010echo gradient echo T2*.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>For patients, conventional MRI indicators (presence and grades of T2 ISI), DWI indicators (neurite orientation dispersion and density imaging [NODDI]\u2010derived isotropic volume fraction [ISOVF], intracellular volume fraction, and orientation dispersion index [ODI], diffusion tensor imaging [DTI]\u2010derived fractional anisotropy [FA] and mean diffusivity [MD], and diffusion kurtosis imaging [DKI]\u2010derived FA, MD, and mean kurtosis), clinical conditions, and modified Japanese Orthopaedic Association (mJOA) were recorded before the surgery. Neurologic function improvement was measured by the 3\u2010month follow\u2010up recovery rate (RR). For HCs, DWI, and mJOA were measured as baseline comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Continuous (categorical) variables were compared between patients and HCs using Student's <jats:italic>t<\/jats:italic>\u2010tests or Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests (chi\u2010square or Fisher exact tests). The relationships between DWI metrics\/conventional MRI findings, and the pre\u2010operative mJOA\/RR were assessed using correlation and multivariate analysis. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among patients, grades of T2 ISI were not correlated with pre\u2010surgical mJOA\/RR (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.717\u00a0 and\u00a00.175, respectively). NODDI ODI correlated with pre\u2010operative mJOA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.31). DTI FA, DKI FA, and NODDI ISOVF were correlated with the recovery rate (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.31, 0.41, and \u22120.34, respectively). In multivariate analysis, NODDI ODI (DTI FA, DKI FA, NODDI ISOVF) significantly contributed to the pre\u2010operative mJOA (RR) after adjusting for age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>DTI FA, DKI FA, and NODDI ISOVF are predictors for prognosis in patients with CSM. NODDI ODI can be used to evaluate CSM severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>5<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27894","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T16:06:46Z","timestamp":1629734806000},"page":"930-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Utility of Advanced <scp>DWI<\/scp> in the Detection of Spinal Cord Microstructural Alterations and Assessment of Neurologic Function in Cervical Spondylotic Myelopathy Patients"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-1558","authenticated-orcid":false,"given":"Meng\u2010Ze","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Qiang","family":"Ou\u2010Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Peking University Third Hospital  Beijing China"},{"name":"Engineering Research Center of Bone and Joint Precision Medicine  Beijing China"},{"name":"Beijing Key Laboratory of Spinal Disease Research  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-3166","authenticated-orcid":false,"given":"Jian\u2010Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Chang","family":"Zhang","sequence":"additional","affiliation":[{"name":"MR Collaboration, Siemens Healthcare Ltd.  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