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However, little is known about the impact of body mass index (BMI) on LA strains measured using cardiac magnetic resonance feature tracking (MR\u2010FT).<\/jats:p><\/jats:sec>Purpose<\/jats:title>To investigate the additive effect of BMI on LA functional remodeling using MR\u2010FT as well as to explore abnormal atrioventricular interaction in T2DM patients.<\/jats:p><\/jats:sec>Study Type<\/jats:title>Retrospective.<\/jats:p><\/jats:sec>Population<\/jats:title>One hundred and fifty\u2010nine T2DM patients (53, 34, and 72 normal\u2010weight, overweight, and obese individuals) and 105 non\u2010diabetic controls (46, 32, and 27 normal\u2010weight, overweight, and obese individuals).<\/jats:p><\/jats:sec>Field Strength\/Sequence<\/jats:title>3.0\u2009T<\/jats:styled-content>\/balanced steady\u2010state free precession.<\/jats:p><\/jats:sec>Assessment<\/jats:title>LA reservoir strain (\u03b5<\/jats:italic>s<\/jats:italic><\/jats:sub>), conduit strain (\u03b5<\/jats:italic>e<\/jats:italic><\/jats:sub>), and active strain (\u03b5<\/jats:italic>a<\/jats:italic><\/jats:sub>) and their corresponding strain rates (SRs, SRe, SRa) were measured together with left ventricular (LV) radial, circumferential, and longitudinal peak strain, peak systolic strain rate, and peak diastolic strain rate.<\/jats:p><\/jats:sec>Statistical Tests<\/jats:title>Student's t<\/jats:italic>\u2010test or Mann\u2013Whitney U<\/jats:italic> test, one\u2010way ANOVA, univariate and multivariate linear regression. A P<\/jats:italic> value <0.05 was considered statistically significant.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared to controls in the same BMI category, T2DM patients had significantly decreased reservoir and conduit function, while pump function was not significantly different (\u03b5<\/jats:italic>a<\/jats:italic><\/jats:sub> and SRa: P<\/jats:italic>\u00a0=\u00a00.757 and 0.583 for normal\u2010weight, P<\/jats:italic>\u00a0=\u00a00.171 and 0.426 for overweight, P<\/jats:italic>\u00a0=\u00a00.067 and 0.330 for obese). LA strains were significantly correlated with BMI (r<\/jats:italic>\u00a0=\u00a0\u22120.346 for \u03b5<\/jats:italic>s<\/jats:italic><\/jats:sub>, \u22120.345 for \u03b5<\/jats:italic>e<\/jats:italic><\/jats:sub>) in T2DM patients. Multivariable linear regression analysis indicated that BMI was independently associated with LA \u03b5<\/jats:italic>s<\/jats:italic><\/jats:sub> and \u03b5<\/jats:italic>e<\/jats:italic><\/jats:sub>, LV global longitudinal strain was independently associated with LA \u03b5<\/jats:italic>s<\/jats:italic><\/jats:sub> and \u03b5<\/jats:italic>a<\/jats:italic><\/jats:sub>, and LV circumferential peak diastolic strain rate was independently associated with LA \u03b5<\/jats:italic>e<\/jats:italic><\/jats:sub>.<\/jats:p><\/jats:sec>Data Conclusion<\/jats:title>These findings suggest that the coexistence of increased body weight and T2DM patients can exacerbate the impairment of LA strains and indicate abnormal atrioventricular interactions.<\/jats:p><\/jats:sec>Level of Evidence<\/jats:title>3<\/jats:p><\/jats:sec>Technical Efficacy<\/jats:title>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27931","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T10:56:17Z","timestamp":1632308177000},"page":"1461-1475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of BMI<\/scp> on Left Atrial Strain and Abnormal Atrioventricular Interaction in Patients With Type 2 Diabetes Mellitus: A Cardiac Magnetic Resonance Feature Tracking Study"],"prefix":"10.1002","volume":"55","author":[{"given":"Meng\u2010ting","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Radiology West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-9887","authenticated-orcid":false,"given":"Ying\u2010kun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Birth Defects and Related 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