{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:24:44Z","timestamp":1781652284707,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["12184"],"award-info":[{"award-number":["12184"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance imaging (MRI) is increasingly being used in the diagnosis and treatment planning of uveal melanoma (UM), the most common primary intraocular tumor. Initially, 7\u2009T MRI was primarily used, but more recently these techniques have been translated to 3\u2009T, as it is more commonly available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Compare the diagnostic performance of 3\u2009T and 7\u2009T MRI of UM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010seven <jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content> patients (19% female).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2009T: T1\u2010 and T2\u2010weighted three\u2010dimensional (3D) spin echo (SE) and multi\u2010slice (MS) SE, 7\u2009T: T1\u2010weighted 3D gradient echo (GE), T2\u2010weighted 3D SE and MS SE, 3\u2009T and 7\u2009T GE dynamic contrast\u2010enhanced. T1 weighted images: acquired before and after Gadolinium (Gd) administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>For all sequences, scan and diagnostic quality was quantified using a 5\u2010point Likert scale. Signal intensities on T1 and T2 relative to choroid and eye muscle respectively were assessed as well as the tumor prominence. Finally, the perfusion time\u2010intensity curves (TICs) were classified as plateau, progressive, or wash\u2010out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Image quality scores were compared between both field strengths using Wilcoxon signed\u2010rank and McNemar tests. Paired <jats:italic>t<\/jats:italic>\u2010tests and Bland\u2013Altman were used for comparing tumor prominences. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Image quality was comparable between 3\u2009T and 7\u2009T, for 3DT1, 3DT2, 3DT1Gd (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.86; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.34; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.78, respectively) and measuring tumor dimensions (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.40). 2DT1 and 2DT2 image quality were rated better on 3\u2009T compared to 7\u2009T. Most UM had the same relative signal intensities at 3\u2009T and 7\u2009T on T1 (17\/21) and T2 (13\/17), and 16\/18 diagnostic TICs received the same classification. Tumor prominence measurements were similar between field strengths (95% confidence interval: \u22120.37\u2009mm to 0.03\u2009mm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.097).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Diagnostic performance of the evaluated 3\u2009T protocol proved to be as capable as 7\u2009T, with the addition of 3\u2009T being superior in assessing tumor growth into nearby anatomical structures compared to 7\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27939","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T10:40:34Z","timestamp":1634726434000},"page":"1504-1515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Comparison of <scp>3\u2009T<\/scp> and <scp>7\u2009T MRI<\/scp> for the Clinical Evaluation of Uveal Melanoma"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1104-4418","authenticated-orcid":false,"given":"Michael C.Y.","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3423-9370","authenticated-orcid":false,"given":"Myriam G.","family":"Jaarsma\u2010Coes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa A.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna","family":"Zwirs \u2010 Grech Fonk","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-3868","authenticated-orcid":false,"given":"Gregorius P.M.","family":"Luyten","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  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