{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:00:47Z","timestamp":1773295247670,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite concerns about safety, gadolinium\u2010based contrast agents (GBCAs) are still used for abdominal and pelvic imaging during pregnancy. Researchers have mainly focused on teratogenicity, while very little is known about their possible direct effects on uterine contractility, yet free gadolinium potentially impacts contractility through interaction with calcium channels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate possible effects of selected GBCAs (namely gadoteridol, gadoversetamide, gadobutrol, gadoterate meglumine, and gadoxetic acid) on the contractility of rat myometrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>In vitro organ bath study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Model<\/jats:title><jats:p>Myometria were isolated from adult (10\u201312\u2009weeks old) Sprague Dawley rats, both pregnant (<jats:italic>N<\/jats:italic>\u00a0=\u00a08) and nonpregnant (<jats:italic>N<\/jats:italic>\u00a0=\u00a036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>NA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Myometrial strips were suspended in tissue bath containing physiological saline and isometric contractions were recorded. GBCAs were added to the tissue bath cumulatively, and their effects on contractility parameters (quantified by amplitude, frequency, and area under contractility curve [AUC]) were evaluated by 10\u2010minute intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Normality data, checked by Shapiro\u2013Wilk test, were transformed by arcsine when needed. One\u2010 or two\u2010way analysis of variance was performed, where appropriate, followed by Student\u2013Newman\u2013Keuls test. A <jats:italic>P<\/jats:italic> value of &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All of the assayed GBCAs elicited some alterations in the myometrial contractility in a concentration\u2010dependent manner. Gadoterate meglumine, gadoxetic acid, and gadoversetamide caused a concentration\u2010dependent significant attenuation in AUC (oxytocin\u2010induced, from 100% during control period to 45.1\u2009\u00b1\u20099.0% (nonpregnant) and 59.9\u2009\u00b1\u20098.5% (pregnant), for 90\u2009\u03bcM gadoterate meglumine; respectively), and frequency of the spontaneous and oxytocin\u2010induced contractions. Gadobutrol and gadoteridol at highest dose significantly attenuated mean AUC and frequency of oxytocin\u2010induced contractions of nonpregnant myometrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Results from this in vitro study indicate that GBCAs elicit modulation of myometrial contractions at clinically relevant concentrations. These effects may account, at least partially, for the known potential side effects (rare cases of miscarriages and elective abortion) of these agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 5<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.27979","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T11:21:07Z","timestamp":1635765667000},"page":"1761-1770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigation of Effects of <scp>Gadolinium\u2010Based<\/scp> Contrast Agents on Uterine Contractility Using Isolated Rat Myometrium"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6513-0656","authenticated-orcid":false,"given":"G\u00fclseren","family":"Din\u00e7","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Karadeniz Technical University, Faculty of Medicine  Trabzon Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-9377","authenticated-orcid":false,"given":"Arif K.","family":"Saliho\u011flu","sequence":"additional","affiliation":[{"name":"Department of Physiology Karadeniz Technical University, Faculty of Medicine  Trabzon Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4514-6893","authenticated-orcid":false,"given":"Burak","family":"Ozgoren","sequence":"additional","affiliation":[{"name":"Department of Physiology Karadeniz Technical University, Faculty of Medicine  Trabzon Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6680-1156","authenticated-orcid":false,"given":"Sel\u00e7uk","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Department of Radiology Karadeniz Technical University, Faculty of Medicine  Trabzon Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-9564","authenticated-orcid":false,"given":"Ahmet","family":"Ayar","sequence":"additional","affiliation":[{"name":"Department of Physiology Karadeniz Technical University, Faculty of Medicine  Trabzon Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12126"},{"key":"e_1_2_6_3_1","unstructured":"ACR.ACR manual on contrast media.2020. 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