{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:41:21Z","timestamp":1770568881368,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019396","name":"Anhui Province Key Laboratory of Medical Physics and Technology","doi-asserted-by":"publisher","award":["LMPT201904"],"award-info":[{"award-number":["LMPT201904"]}],"id":[{"id":"10.13039\/501100019396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients receiving cranial radiation face the risk of delayed brain dysfunction. However, an early medical imaging marker is not available until irreversible morphological changes emerge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the micromorphological white matter changes during the radiotherapy session by utilizing an along\u2010tract analysis framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eighteen nasopharyngeal carcinoma (two female) patients receiving cranial radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0\u2009T; Diffusion tensor imaging (<jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\u2010weighted images (<jats:styled-content style=\"fixed-case\">T1W<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">T2W<\/jats:styled-content>); computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Patients received three DTI imaging scans during the radiotherapy (RT), namely the baseline scan (1\u20132\u2009days before RT began), the middle scan (the middle of the RT session), and the end scan (1\u20132\u2009days after RT ended). Twelve fibers were segmented after whole\u2010brain tractography. Then, the fractional anisotropy (FA) values and the cumulative radiation dose received for each fiber streamline were resampled and projected into their center fiber.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>The contrast among the three scans (P1: middle scan\u2013baseline scan; P2: end scan\u2013middle scan; P3: end scan\u2013baseline scan) were compared using the linear mixed model for each of the 12 center fibers. Then, a dose\u2013responsiveness relationship was performed using Pearson correlation. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of the 12 center fibers showed significant changes of FA values during the RT but with heterogeneous patterns. The significant changes along a specific center fiber were associated with their cumulative dose received (Genu: P1 <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.6182, P2 <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.5907; Splenium: P1 <jats:italic>r<\/jats:italic>\u00a0=\u00a00.4055, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.1063, P2 <jats:italic>r<\/jats:italic>\u00a0=\u00a00.6742; right uncinate fasciculus: P1 <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.3865, P2 <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.4912, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0533; right corticospinal tract: P1 <jats:italic>r<\/jats:italic>\u00a0=\u00a00.4273, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.1122, P2 <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.6885).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The along\u2010tract analysis might provide sensitive measures on the early\u2010onset micromorphological changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28018","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T11:34:00Z","timestamp":1638444840000},"page":"210-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early\u2010Onset Micromorphological Changes of Neuronal Fiber Bundles During Radiotherapy"],"prefix":"10.1002","volume":"56","author":[{"given":"Jin","family":"Liu","sequence":"first","affiliation":[{"name":"Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences  Hefei China"},{"name":"University of Science and Technology of China  Hefei China"},{"name":"Hefei Cancer Hospital, 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