{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:21:35Z","timestamp":1754194895541,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T00:00:00Z","timestamp":1640390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Gadobutrol (GB) and gadoterate meglumine (GM) are contrast agents used for contrast\u2010enhanced magnetic resonance angiography (CEMRA). Supraaortic vasculature (SAV) CEMRAs are used to evaluate stroke risk and neurologic symptoms. There is a need to compare the SAV CEMRA image quality obtained with GB and GM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To intra\u2010individually compare MRA images obtained with equimolar GB and GM at 1.5\u00a0T in the SAV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective, crossover.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twenty\u2010eight subjects (54\u2009\u00b1\u200913\u2009years; 17 female).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">1.5\u2009T<\/jats:styled-content>; three\u2010dimensional (<jats:styled-content style=\"fixed-case\">3D)<\/jats:styled-content> gradient recalled echo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Quantitative image quality was measured by normalized signal intensity (SI<jats:sub>n<\/jats:sub>) [SI<jats:sub>n<\/jats:sub>\u00a0=\u00a0SI blood\/SD blood] and contrast ratio (CR) [CR\u00a0=\u00a0SI blood\/SI muscle], determined by an observer (JWC) with 1\u2009year of vascular imaging experience. Three radiologists (AS, PA, and MU) with (5, 5, and 6\u2009years of) vascular imaging experience evaluated image quality by Likert\u2010scale ratings (of image impression, wall conspicuity, and artifact absence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>SI<jats:sub>n<\/jats:sub> and CR were compared with paired <jats:italic>t<\/jats:italic>\u2010tests or Wilcoxon signed\u2010rank tests and Bland\u2013Altman plots. Qualitative ratings were compared with Wilcoxon signed\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference in SI<jats:sub>n<\/jats:sub> was found between GB and GM. CRs with GB were significantly higher than GM at the right common carotid (6.9\u2009\u00b1\u20092.5 vs. 4.8\u2009\u00b1\u20091), left internal carotid (7.3\u2009\u00b1\u20092 vs. 4.4\u2009\u00b1\u20091.2), right internal carotid (7.7\u2009\u00b1\u20092.2 vs. 5\u2009\u00b1\u20091.1), and left vertebral (6.6\u2009\u00b1\u20092.2 vs. 4.5\u2009\u00b1\u20091.1) arteries. Bland\u2013Altman plots showed relatively greater differences between GB and GM at higher CRs and SI<jats:sub>n<\/jats:sub>s. GM showed significantly higher artifact than GB (3.56\u2009\u00b1\u20090.52 vs. 3.36\u2009\u00b1\u20090.46) and significantly lower overall image quality (10.73\u2009\u00b1\u20091.45 vs. 11.26\u2009\u00b1\u20091.58) at the left vertebral artery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>At 1.5\u00a0T and equimolar demonstration, GB (0.1\u00a0mL\/kg, i.e., 0.1\u2009mmol\/kg) showed higher CRs in the SAV compared to GM (0.2\u00a0mL\/kg, i.e., 0.1\u2009mmol\/kg) at most vessels. Subjective image quality was not significantly different between the two agents for most vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28044","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T16:29:10Z","timestamp":1640449750000},"page":"440-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>MRA<\/scp> of the Supraaortic Vasculature: Comparison of Gadobutrol and Gadoterate Meglumine at 1.<scp>5 T<\/scp>"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-1146","authenticated-orcid":false,"given":"John W.","family":"Cerne","sequence":"first","affiliation":[{"name":"Department of Radiology Northwestern University Feinberg School of Medicine  Chicago 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