{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:27:44Z","timestamp":1790393264074,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["2016WS0529"],"award-info":[{"award-number":["2016WS0529"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800840"],"award-info":[{"award-number":["81800840"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH288"],"award-info":[{"award-number":["ZR2020MH288"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,9]]},"abstract":"\n Background<\/jats:title>\n Cerebral microbleeds (CMBs) have been recognized to play an important role in cognitive impairment of cerebral small vessel disease (CSVD) patients. However, the mechanism of this effect is still unclear.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n Comparing the susceptibility values in the selected subcortical gray matter structures of CSVD patients without CMBs (CSVD\u2010N) and with CMBs (CSVD\u2010C) as well as healthy controls (HCs).<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n Sixty\u2010nine CSVD patients and 28 HCs were included; 24 CSVD patients (34.78%) had CMBs and 45 CSVD patients (65.22%) had no CMBs.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n All subjects were imaged on a 3.0\u2009T MR scanner. The protocol consisted of a three\u2010dimensional (3D) T1\u2010weighted sequence and a 3D multi\u2010echo gradient echo (mGRE) sequence. Brain QSM maps were computed from mGRE data using the morphology\u2010enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference algorithm (MEDI+0).<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n The mean susceptibility value within each region of interest was recorded. All participants underwent the cognitive assessment. Brain iron deposition burden of CMB lesions of every CSVD\u2010C patient was computed.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n One\u2010way analysis of variance test followed by Tukey's honest significance test and Kruskal\u2013Wallis test were used with significance level of 0.05. Stepwise multivariate linear analysis was used to explore the factors influencing cognitive scores.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Montreal cognitive assessment (MoCA), trail\u2010making test (TMT)\u2010A and TMT\u2010B scores in the three groups were significantly different (all\n P<\/jats:italic>\n \u2009<\u20090.05). Stepwise multivariate linear regression analysis revealed that the factors influenced MoCA scores were having CMBs (\n P<\/jats:italic>\n \u2009<\u20090.05), white matter hyperintensities (\n P<\/jats:italic>\n \u2009<\u20090.05), lacunes (\n P<\/jats:italic>\n \u2009<\u20090.05) in brain, and the brain iron deposition burden of CMB lesions (\n P<\/jats:italic>\n \u2009<\u20090.05) and for TMT scores (TMT\u2010A\u2009+\u2009TMT\u2010B), the influencing factors were age (\n P<\/jats:italic>\n \u2009<\u20090.05), education years (\n P<\/jats:italic>\n \u2009<\u20090.05), and the brain iron deposition burden of CMB lesions (\n P<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n The higher iron deposition burden of CMB lesions in brain may be an imaging quantitative marker of cognitive decline in patients with CSVD\u2010C.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 1<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.28092","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T09:46:56Z","timestamp":1643622416000},"page":"904-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cerebral Microbleeds Are Associated With Increased Brain Iron and Cognitive Impairment in Patients With Cerebral Small Vessel Disease: A Quantitative Susceptibility Mapping Study"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9392-6600","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University 95 Yong\u2010an Road Beijing 10050 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-7694","authenticated-orcid":false,"given":"Thanh D.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medical College 407 East 61st Street New York 10044 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8054-5849","authenticated-orcid":false,"given":"Qihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medical College 407 East 61st Street New York 10044 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-625X","authenticated-orcid":false,"given":"Lingfei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical University 324 Jing\u2010wu Road Jinan 250021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1404-8526","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medical College 407 East 61st Street New York 10044 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022485"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.487173"},{"issue":"4","key":"e_1_2_7_5_1","first-page":"637","article-title":"Histopathologic analysis of foci of signal loss on gradient\u2010echo T2*\u2010weighted MR images in patients with spontaneous intracerebral hemorrhage: Evidence of microangiopathy\u2010related 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