{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:56:59Z","timestamp":1791813419040,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mitral regurgitation (MR) is a comorbidity of myocardial infarction (MI), which may promote the incidence of adverse cardiovascular clinical events. However, it is not yet completely understood how MR in MI patients is associated with impaired myocardial deformation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the damaging myocardium effects of MR in MI patients in terms of the global peak strain (PS) and left ventricular (LV) function, and evaluate the independent risk factors impacting LV deformation after MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>One hundred eighty\u2010six MI patients (17.7% female) and 84 normal control subjects (27.4% female).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field strength\/sequence<\/jats:title><jats:p>3.0T; late gadolinium enhancement sequence, balanced steady\u2010state free precession.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>LV function and LV global PS (global radial peak strain [GRPS]; global circumferential peak strain [GCPS]; and global longitudinal peak strain [GLPS]) were compared among normal controls, MI without MR (MR\u2212) and MI with MR (MR+, mild, moderate, severe) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>One\u2010way analysis of variance (ANOVA) test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, Kruskal\u2013Wallis test, and multiple linear regressions were used. A <jats:italic>P<\/jats:italic> value &lt;0.05 indicated statistically significant difference (two\u2010tailed).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MI (MR+) patients showed significantly lower LV global PS than both MI (MR\u2212) and control groups in three directions (GRPS 16.66 \u00b1\u20097.43%; GCPS \u221211.27 \u00b1\u20094.27%; GLPS \u22127.75 \u00b1\u20093.44%), and significantly higher LV end\u2010systolic (128.85 [87.91, 188.01] mL) and end\u2010diastolic volumes (210.29 [164.07, 264.00] mL) and significantly lower LV ejection fraction (38.23 \u00b1\u200913.02%). Multiple regression analysis demonstrated that MR was independently associated with LV GCPS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.268) and GLPS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.320). LV infarct size was an independent indicator of LV GRPS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.215) and GCPS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.222). LV end\u2010diastolic volume was an independent indicator of LV GRPS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.518), GCPS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.503), and GLPS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.331).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>MR may further exacerbate the reduction of LV global peak strains and function. The MR, infarct size, and LV end\u2010diastolic volume can be used as independent association indicators for LV global PS in MI (MR+) patients.<\/jats:p><jats:p>Level of Evidence: 4<\/jats:p><jats:p>Technical Efficacy Stage: 2<\/jats:p><jats:p>TOC Category: Chest.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28101","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T17:57:12Z","timestamp":1644256632000},"page":"790-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Mitral Regurgitation on Left Ventricular Deformation in Myocardial Infarction Patients: Evaluation by Cardiac Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"56","author":[{"given":"Xiao\u2010Ling","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Department of Radiology, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-9887","authenticated-orcid":false,"given":"Ying\u2010Kun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Second University Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-4798","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Xi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-7697","authenticated-orcid":false,"given":"Zhi\u2010Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan 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