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Contrast\u2010enhanced FLAIR is known to be highly sensitive to low concentrations of gadolinium within the fluid. Accordingly, recent research has suggested the potential utility of contrast\u2010enhanced FLAIR in various kinds of disease, such as Meniere's disease, seizure, stroke, traumatic brain injury, and brain metastasis, in addition to being used for visualizing glymphatic dysfunction. However, its potential applications have been reported sporadically in an unorganized manner. Furthermore, the exact mechanism for its superior sensitivity to low concentrations of gadolinium has not been fully understood. Rapidly developing magnetic resonance technology and unoptimized parameters for FLAIR may challenge its accurate application in clinical practice. This review provides the fundamental mechanism of contrast\u2010enhanced FLAIR, systematically describes its current and potential clinical application, and elaborates on technical considerations for its optimization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>5<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28117","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T08:10:41Z","timestamp":1644999041000},"page":"341-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Contrast\u2010Enhanced Fluid\u2010Attenuated Inversion Recovery in Neuroimaging: A Narrative Review on Clinical Applications and Technical Advances"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-2432","authenticated-orcid":false,"given":"Sung 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