{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:53:42Z","timestamp":1790816022887,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009989","name":"Nova Scotia Research Innovation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009989","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,11]]},"abstract":"Background<\/jats:title>Non\u2010alcoholic fatty liver disease (NAFLD) is increasingly common worldwide and can lead to the development of cirrhosis, liver failure and cancer. Virtual magnetic resonance elastography (VMRE), which is based on a shifted apparent diffusion coefficient (sADC), is a potential noninvasive method to assess liver fibrosis without the specialized hardware and expertise required to implement traditional MR elastography (MRE). Although hepatic steatosis is known to confound ADC measurements, previous studies using VMRE have not corrected for hepatic fat fraction.<\/jats:p><\/jats:sec>Purpose<\/jats:title>To compare VMRE, corrected for the confounding effects of unsuppressed fat signal, to MRE and biopsy in subjects with suspected NAFLD.<\/jats:p><\/jats:sec>Study Type<\/jats:title>Prospective, cross\u2010sectional.<\/jats:p><\/jats:sec>Population<\/jats:title>A total of 49 adult subjects with suspected NAFLD (18 male; median age 55\u2009years, range 33\u201374\u2009years) who underwent liver biopsy.<\/jats:p><\/jats:sec>Field strength\/Sequence<\/jats:title>\u20093T, diffusion\u2010weighted spin echo planar, chemical\u2010shift encoded (IDEAL IQ) and MRE sequences.<\/jats:p><\/jats:sec>Assessment<\/jats:title>Two observers drew regions of interest on sADC, proton density fat fraction and MRE\u2010derived stiffness maps. Fat\u2010corrected sADC values were used to calculate the diffusion\u2010based shear modulus according to the VMRE method. Predicted fibrosis stage for MRE and VMRE was determined using previously published cut\u2010off values.<\/jats:p><\/jats:sec>Statistical Tests<\/jats:title>The relationship between VMRE and MRE was assessed with least\u2010squares linear regression (coefficient of determination, R<\/jats:italic>2<\/jats:sup>). Agreement between MRE and VMRE\u2010predicted fibrosis stage was evaluated with a kappa coefficient and accuracy compared using McNemar's test. A one\u2010way ANOVA determined if the fat\u2010corrected sADC (VMRE) and MRE differed by fibrosis stage. A P<\/jats:italic> value\u2009<\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec>Results<\/jats:title>Least squares regression of VMRE vs. MRE revealed R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.046 and a slope that was not significantly different from zero (P<\/jats:italic>\u00a0=\u00a00.14). There was no agreement between MRE and VMRE\u2010predicted fibrosis stage (kappa\u00a0=\u00a0\u22120.01). The proportion of correctly predicted fibrosis stage was significantly higher for MRE compared to VMRE. MRE was significantly associated with fibrosis stage, but fat\u2010corrected sADC was not (P<\/jats:italic>\u00a0=\u00a00.24).<\/jats:p><\/jats:sec>Data Conclusion<\/jats:title>Fat\u2010corrected VMRE was not associated with fibrosis stage in NAFLD. Further investigation is required if VMRE is to be considered in subjects with NAFLD.<\/jats:p><\/jats:sec>Evidence Level<\/jats:title>1<\/jats:p><\/jats:sec>Technical Efficacy<\/jats:title>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28154","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T14:12:59Z","timestamp":1647267179000},"page":"1448-1456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Prospective Evaluation of Virtual MR<\/scp> Elastography With Diffusion\u2010Weighted Imaging in Subjects With Nonalcoholic<\/scp> Fatty Liver Disease"],"prefix":"10.1002","volume":"56","author":[{"given":"Elyisha","family":"Hanniman","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology Dalhousie University Halifax Nova Scotia B3H 2Y9 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