{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:47:57Z","timestamp":1793810877929,"version":"4.6.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["R01\u2010AR064771"],"award-info":[{"award-number":["R01\u2010AR064771"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["R01\u2010AR078917"],"award-info":[{"award-number":["R01\u2010AR078917"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Synovial inflammation is a risk factor for osteoarthritis (OA). But to date, there is limited information on how inflammation impacts progression of knee OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate how sustained synovitis, assessed with semi\u2010quantitative magnetic resonance imaging (MRI) scores, impacts progression of knee degenerative changes over 4\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>\n                      In 249 participants (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u2009132 women [53%]), from the Osteoarthritis Initiative (OAI) two definitions for synovitis were used resulting in two groups of participants with sustained synovitis at baseline, 2\u2010year, and 4\u2010year follow\u2010up (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a080 and\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0132), and two groups without synovitis at all three time points (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a081 and\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3\u2009T intermediate\u2010weighted (IW) turbo spin\u2010echo (TSE) sequence and three\u2010dimensional (3D) dual\u2010echo steady\u2010state (DESS) sequence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Synovitis was scored semi\u2010quantitatively using the Anterior Cruciate Ligament Osteoarthritis Score (ACLOAS), MRI Osteoarthritis Knee Score (MOAKS), and synovial proliferation score (SPS). Two MRI\u2010based definitions of synovitis were used: (i) score \u22652 based on cumulative score of MOAKS and ACLOAS, and (ii) score \u22653 based on the cumulative score of ACLOAS, MOAKS, and SPS. Changes in structural abnormalities from baseline to year 4 measured using the whole\u2010organ MRI score (WORMS) were defined as outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Linear regression models were used to compare the differences in longitudinal changes in WORMS scores between participants with and without sustained synovitis for each definition of sustained synovitis. A\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value of &lt;0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significantly higher rates of progression were found in participants with synovitis for patellar (Beta coeff.\u00a0=\u00a00.29) and medial tibial cartilage abnormalities (Beta coeff.\u00a0=\u00a00.29) for definition (i). For definition (ii), patellar (Beta coeff.\u00a0=\u00a00.36) and medial femoral cartilage (Beta coeff.\u00a0=\u00a00.30) abnormalities demonstrated significant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>Greater progression of structural degenerative disease was observed in individuals with sustained synovitis compared to those without sustained synovitis, suggesting that sustained synovitis is associated with progressive OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 2<\/jats:p>\n                  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