{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:17:30Z","timestamp":1768835850404,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971588"],"award-info":[{"award-number":["81971588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite a recommended multidimensional approach for pulmonary hypertension (PH) risk stratification and guidance of treatment decisions, this may not always be achievable in patients with advanced disease. One issue is the lack of an imaging modality to assess right ventricular (RV) structure and function abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the risk stratification and prognostic value of cardiac MR feature tracking (MR\u2010FT)\u2010derived RV strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 80 patients with idiopathic pulmonary artery hypertension (<jats:italic>N<\/jats:italic>\u00a0=\u00a052) or chronic thromboembolic PH (<jats:italic>N<\/jats:italic>\u00a0=\u00a028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength<\/jats:title><jats:p>A 1.5\u2009T or 3.0\u2009T, balanced steady\u2010state free precession sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>All patients underwent laboratory testing, right heart catheterization, and MR imaging (and in 37 cases, a cardiopulmonary exercise test was also performed) within a 1\u2010month period. Cardiac functional parameters and both global longitudinal strain (GLS) and global circumferential strain (GCS) were analyzed. Patients were stratified into low, intermediate, and high\u2010risk groups by guideline suggested stratified values of risk factors. The combined endpoint was death or hospitalization for congestive heart failure assessed during follow\u2010up since the date of MR examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Kolmogorov\u2013Smirnov's test, independent\u2010sample <jats:italic>t<\/jats:italic>\u2010tests, Wilcoxon's rank\u2010sum tests, one\u2010way analysis of variance, \u03c7<jats:sup>2<\/jats:sup> tests or Fisher's exact test, receiver operating characteristic analysis, Kaplan\u2013Meier survival analysis, and Cox regression analysis. A <jats:italic>P<\/jats:italic> value\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up duration was 3.4\u2009years. Thirty\u2010five patients presented with combined endpoint including 10 cardiac deaths. RV structural and deformation impairments were significantly associated with combined endpoint (ejection fraction: 31.3%\u2009\u00b1\u200913.2% vs. 38.0%\u2009\u00b1\u200914.8%, hazard ratio [HR: 0.974; GLS: \u221214.5 [\u221218.6, \u221210.9] % vs. \u221220.4 [\u221226.0, \u221213.2] %, HR: 1.071; GCS: \u22129.8 [\u221214.5, \u22127.3] % vs. \u221212.3 [\u221219.9, \u22128.4] %, HR: 1.059). There were significant differences in RVGLS among low, intermediate, and high\u2010risk groups (\u221219.3%\u2009\u00b1\u20097.2% vs. \u221217.3%\u2009\u00b1\u20099.4% vs. \u221211.5%\u2009\u00b1\u20094.4% by cardiac functional class, \u221221.8%\u2009\u00b1\u20097.3% vs. \u221219.4%\u2009\u00b1\u20098.2% vs. \u221212.7\u2009\u00b1\u20095.3% by NT\u2010proBNP, \u221219.7%\u2009\u00b1\u20097.7 vs. \u221215.8%\u2009\u00b1\u20096.5% vs. \u221212.6%\u2009\u00b1\u20098.2% by cardiac index).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>RV deformation may aid risk stratification in patients with PH, providing crucial information for RV remodeling, pulmonary hemodynamic condition and exercise capacity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28291","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T12:12:49Z","timestamp":1655467969000},"page":"545-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk Stratification and Outcomes in Patients With Pulmonary Hypertension: Insights into Right Ventricular Strain by <scp>MRI<\/scp> Feature tracking"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9766-860X","authenticated-orcid":false,"given":"Di","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Pulmonary 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National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Key Laboratory of Cardiovascular Imaging (Cultivation) Chinese Academy of Medical Sciences  Beijing 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