{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:59:46Z","timestamp":1791907186806,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Measurement of ventricular volumes and function using MRI is an important tool in pediatric congenital heart disease. However, normal values for children are sparce and analysis methods are inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To propose biventricular reference values in children for two MRI postprocessing (contouring) techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>A total of 154 children from two institutions (13.9\u00a0\u00b1\u20092.8\u2009years; 101 male) that were referred for a clinical MRI study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>1.5\u2009T; balanced steady\u2010state free precession (<jats:styled-content style=\"fixed-case\">bSSFP<\/jats:styled-content>) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Left ventricular (LV) and right ventricular (RV) end\u2010diastolic and end\u2010systolic volumes (LVEDV, LVESV, RVEDV, RVESV) and end\u2010diastolic and end\u2010systolic myocardial mass (LVEDMM, LVESMM, RVEDMM, RVESMM) were measured from short\u2010axis images using two contouring techniques: 1) papillary muscles, trabeculations and the moderator band were included in the ventricular blood volume and excluded from the myocardial mass, 2) papillary muscles, trabeculations and the moderator band were excluded from the ventricular volume and included in the ventricular mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Univariable and multivariable linear regression models were used to evaluate relationships between sex, weight, height, body surface area (BSA) and age and volumetric results. Reference graphs and tables were created with the LMS\u2010method. Contouring techniques were compared by intraclass correlation, regression analysis and Bland\u2013Altman plots. A <jats:italic>P<\/jats:italic> value\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Height and BSA were significantly associated with LVESV (method 1) and with LVEDV and RVEDV (method 2). LVESV (method 2), RVESV (both methods), RVEDV (method 1), and LVEDMM and RVEDMM (both methods), showed significant associations with height and weight. LVSV and RVSV (both methods) were significantly associated with BSA and weight. RVESV (method 1) was significantly associated with age. Gender showed significant associations for all parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>The proposed pediatric reference values can be used in the diagnosis and follow\u2010up of congenital or acquired heart disease and for research purposes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28299","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T15:57:26Z","timestamp":1655481446000},"page":"774-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pediatric Cardiac Magnetic Resonance Reference Values for Biventricular Volumes Derived From Different Contouring Techniques"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-8006","authenticated-orcid":false,"given":"Inga","family":"Voges","sequence":"first","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology University Hospital Schleswig\u2010Holstein  Campus Kiel Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Hamburg\/Kiel\/L\u00fcbeck  Kiel Germany"},{"name":"Medical Faculty Kiel University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amke","family":"Caliebe","sequence":"additional","affiliation":[{"name":"Medical Faculty Kiel University  Germany"},{"name":"Department of Medical Informatics and Statistics University Hospital Schleswig\u2010Holstein  Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Hinz","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology University Hospital Schleswig\u2010Holstein  Campus Kiel Germany"},{"name":"Medical Faculty Kiel University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Boroni Grazioli","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology University Hospital Schleswig\u2010Holstein  Campus Kiel Germany"},{"name":"Medical Faculty Kiel University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik D.","family":"Gabbert","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology University Hospital Schleswig\u2010Holstein  Campus Kiel Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Hamburg\/Kiel\/L\u00fcbeck  Kiel Germany"},{"name":"Medical Faculty Kiel University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piers E. F.","family":"Daubeney","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Royal Brompton Hospital Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm S.","family":"Uebing","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology University Hospital Schleswig\u2010Holstein  Campus Kiel Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Hamburg\/Kiel\/L\u00fcbeck  Kiel Germany"},{"name":"Medical Faculty Kiel University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudley J.","family":"Pennell","sequence":"additional","affiliation":[{"name":"Imperial College  London UK"},{"name":"CMR Unit, Royal Brompton Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Krupickova","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Royal Brompton Hospital Guy's and St Thomas' NHS Foundation Trust  London UK"},{"name":"Imperial College  London UK"},{"name":"CMR Unit, Royal Brompton Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00682-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00610-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1371-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000690"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.859074"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-19"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21662"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00692-2"},{"key":"e_1_2_8_10_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9876.2005.00510.x"},{"key":"e_1_2_8_13_1","unstructured":"GamerM LemonJ FellowsI SinghP.irr: Various Coefficients of Interrater Reliability and Agreement. 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