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However, controversies about the mechanism of WM tract injury exist persistently. Excessive iron accumulation, frequently reported in CADASIL patients, might cause WM tract injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To test the association between iron accumulation and WM tract injury in CADASIL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 35 CADASIL patients (age\u2009=\u200950.4\u2009\u00b1\u20096.4, 62.9% female) and 48 healthy controls (age\u2009=\u200955.7\u2009\u00b1\u20098.0, 68.8% female).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Diffusion\u2010weighted spin\u2010echo echo\u2010planar sequence; enhanced susceptibility\u2010weighted angiography (ESWAN) gradient echo sequence on a 3\u00a0T scanner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The phase images acquired by ESWAN were used to calculate quantitative susceptibility mapping (QSM). Iron accumulation was evaluated in deep gray matters using QSM. WM tract injury was quantified by diffusion metrics based on WM major tracts skeleton. We compared iron deposition between groups and analyzed the correlation between WM tract injury and iron deposition in regions showing significant differences from healthy controls. Exploratory analysis was carried out to investigate whether WM tract injury mediated the relationship between iron deposition and cognitive impairment evaluated by Mini\u2010Mental State Examination (MMSE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>General linear model (GLM), partial correlation, stepwise linear regression and mediation analysis were used. The threshold of statistical significance was set as <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls, CADASIL patients had significantly increased iron deposition in the caudate and putamen. Aberrant iron deposition in these two regions was significantly associated with decreased WM fractional anisotropy (FA) (caudate, <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.373\uff1b putamen, <jats:italic>r<\/jats:italic>\u2009=\u2009\u2212 0.421), and increased radial diffusivity (RD) (caudate, <jats:italic>r<\/jats:italic>\u2009=\u20090.372; putamen, <jats:italic>r<\/jats:italic>\u2009=\u20090.386). Furthermore, WM tract injury mediated the relationship between iron deposition and cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Patients with CADASIL show increased iron deposition in the caudate and putamen that is correlated to WM tract injury, which may in turn mediate the association with cognitive impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28301","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T12:25:39Z","timestamp":1655987139000},"page":"238-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["White Matter Tract Injury by <scp>MRI<\/scp> in <scp>CADASIL<\/scp> Patients is Associated With Iron 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