{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:17:30Z","timestamp":1781651850937,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013130","name":"Center for Neuroscience and Regenerative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Susceptibility\u2010weighted imaging (SWI) provides superior image contrast of cerebral microhemorrhages (CMBs). It is based on a three\u2010dimensional (3D) gradient echo (GRE) sequence with a relatively long imaging time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate whether an accelerated 3D segmented echo planar imaging SWI is comparable to GRE SWI in detecting CMBs in traumatic brain injury (TBI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Four healthy volunteers and 46 consecutive subjects (38.0\u2009\u00b1\u200914.4\u2009years, 16 females; 12 mild, 13 moderate, and 7 severe TBI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A 3\u2009T scanner\/3D gradient echo and 3D segmented echo planar imaging (segEPI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Brain images were acquired using GRE and segEPI in a single session (imaging time\u00a0=\u00a09\u00a0minutes 47\u2009seconds and 1\u00a0minute 30\u2009seconds, respectively). The signal\u2010to\u2010noise ratio (SNR) calculated from healthy volunteer thalamus and centrum semiovale were compared. CMBs were counted by three raters blinded to diagnostic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>A <jats:italic>t<\/jats:italic>\u2010test was used to assess SNR difference. Pearson correlation and Wilcoxon signed\u2010rank test were performed using CMB counts. The intermethod agreement was evaluated using Bland\u2013Altman method. Intermethod and interrater reliabilities of image\u2010based diffuse axonal injury (DAI) diagnoses were evaluated using Cohen's kappa and percent agreement. <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thalamus SNRs were 16.9\u2009\u00b1\u20092.2 and 16.5\u2009\u00b1\u20093 for GRE and segEPI (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.84), respectively. Centrum semiovale SNRs were 25.8\u2009\u00b1\u20094.6 and 21.1\u2009\u00b1\u20092.7 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.13). The correlation coefficient of CMBs was 0.93, and differences were not significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.56\u20130.85). For DAI diagnoses, Cohen's kappa was 0.62\u20130.84 and percent agreement was 85%\u201394%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>CMB counts on segEPI and GRE were highly correlated, and DAI diagnosis was made equally effectively. segEPI SWI can potentially replace GRE SWI in detecting TBI CMBs, especially when time constraints are critical.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>1<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28326","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T18:44:35Z","timestamp":1658256275000},"page":"1529-1535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Segmented <scp>3D<\/scp> Echo Planar Acquisition for Rapid Susceptibility\u2010Weighted Imaging: Application to Microhemorrhage 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