{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:53:08Z","timestamp":1790009588636,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102004"],"award-info":[{"award-number":["82102004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The mechanism driving dysthyroid optic neuropathy (DON) is unclear. Diffusion\u2010tensor imaging (DTI) allows for noninvasively assessing the microstructure of the entire visual pathway and may facilitate a better understanding of the mechanism of DON.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess microstructural changes of the whole visual pathway and to investigate the potential mechanism of trans\u2010synaptic damage\uff08TSD\uff09 pathogenesis in DON with DTI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Cross\u2010sectional.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Sixty\u2010four patients with bilateral thyroid\u2010associated ophthalmopathy (TAO), 30 with and 34 without DON, and 30 age\u2010 and sex\u2010matched healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3 T\/DTI (A single\u2010shot diffusion\u2010weighted echo\u2010planar imaging sequence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Differences in DTI parameters including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in each segment (optic nerve, tract, and radiation) of the entire visual pathway among the groups were compared. The parameters of visual evoked potentials (VEPs), visual field tests, and mean retinal nerve fiber layer (mRNFL) thickness on optical coherence tomography were also compared across patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Student's <jats:italic>t<\/jats:italic>\u2010test, chi\u2010square test; ANOVA with post\u2010hoc testing, interclass correlation coefficient, and correlation analysis. Significance level: <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TAO patients with DON showed significantly reduced mRNFL thickness and abnormal VEPs. There was a tendency for gradually reduced FA and AD, and increased RD and MD from HCs, with non\u2010DON to with DON in optic nerve and tract, statistically. For radiation, the RD and MD showed statistical increase, the AD and FA just showed numerical decrease (<jats:italic>P<\/jats:italic>\u00a0=\u20090.119 and 0.059, respectively). For DON, the FA and MD of visual pathway segments showed correlations with abnormal VEPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>DTI may be a useful tool for detecting microstructural changes in the entire visual pathway in DON. The changes in RNFL thickness and DTI parameters suggested TSD as a potential pathogenic mechanism of DON.<\/jats:p><jats:p>Evidence Level: 4<\/jats:p><jats:p>Technical Efficacy: Stage 5<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28352","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T04:56:08Z","timestamp":1658465768000},"page":"834-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Preliminary Diffusion\u2010Tensor Imaging Evidence for Trans\u2010Synaptic Axonal Degeneration in Dysthyroid Optic Neuropathy Due to Thyroid\u2010Associated Ophthalmopathy"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-8316","authenticated-orcid":false,"given":"Ping","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Guangdong Second Provincial General Hospital  Guangzhou China"},{"name":"Department of Radiology, The Affiliated Tongji Hospital, Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ban","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Tongji Hospital, Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Tongji Hospital, Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Affiliated Tongji Hospital, Tongji Medical College Huazhong University of Science &amp; Technology  Wuhan Hubei 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