{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:23:30Z","timestamp":1747149810175,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX201704"],"award-info":[{"award-number":["ZYLX201704"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010laminar optic nerve invasion (PLONI) is a high\u2010risk factor for the metastasis of retinoblastoma (RB). Unlike conventional MRI, diffusion\u2010weighted imaging (DWI) reflects histopathological features, and may aid the assessment of PLONI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the value of conventional MRI plus DWI in detecting PLONI in RB patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eighty\u2010three RB patients, including 28 with histopathologically proven PLONI and 55 without PLONI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0 T, precontrast axial <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content>\u2010weighted and <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\u2010weighted imaging, <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>, and postcontrast axial, coronal, and oblique\u2010sagittal <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content>\u2010weighted imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>PLONI was assessed using post\u2010enucleation histology and preoperative MRI features (optic nerve signal intensity, enlargement, and enhancement on conventional MRI, and apparent diffusion coefficient [ADC] of the optic nerve on DWI) evaluated by three observers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>MRI features suggesting the presence of PLONI were identified using univariable and multivariable analyses. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to analyze diagnostic performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Optic nerve enhancement and low ADC of the optic nerve were significant indicators of PLONI. ROC curve analysis showed that the AUC of the combination of these two features for detecting PLONI was 0.87 (95% confidence interval [CI]: 0.78\u20130.93). The diagnostic performance of this model was significantly superior to that of optic nerve enhancement alone (0.76, 95% CI: 0.65\u20130.85) and marginally superior to that of the ADC of the affected optic nerve (0.78, 95% CI: 0.68\u20130.87, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.051).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Conventional MRI combined with DWI can improve the detection of PLONI in RB patients over conventional MRI alone.<\/jats:p><jats:p>Evidence Level: 3<\/jats:p><jats:p>Technical Efficacy: Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28429","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T10:51:10Z","timestamp":1663239070000},"page":"1587-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffusion\u2010Weighted <scp>MR<\/scp> Imaging of the Optic Nerve Can Improve the Detection of Post\u2010Laminar Optic Nerve Invasion from Retinoblastoma"],"prefix":"10.1002","volume":"57","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology Beijing Tongren Hospital, Capital Medical University  Beijing China"},{"name":"Dongfang Hospital, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Ophthalmology, Beijing Tongren Eye Center Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"Dongfang Hospital, Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Tongren Hospital, Capital Medical 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