{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:05:32Z","timestamp":1775984732139,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In Duchenne muscular dystrophy (DMD), the right ventricle (RV) tends to be relatively well preserved, but characterization remains difficult due to its complex architecture. Tissue phase mapping (TPM) is a phase contrast cine MRI technique that allows for multidirectional assessment of myocardial velocities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To use TPM to elucidate relationships between myocardial structure, function, and clinical variables in DMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>A total of 20 patients with muscular dystrophy (median age: 16\u2009years); 18 age\u2010matched normal controls (median age: 15\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>Three\u2010directional velocity encoded cine gradient echo sequence (TPM) at 1.5\u00a0T, balanced steady\u2010state free procession (bSSFP), T1 mapping with extracellular volume (ECV), and late gadolinium enhancement (LGE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>TPM in basal, mid, and apical short\u2010axis planes was performed as part of a standard MRI study with collection of clinical data. Radial, circumferential, and longitudinal velocities (Vr, V\u03c6, and Vz, respectively) and corresponding time to peak (TTP) velocities were quantified from TPM and used to calculate RV twist as well as intraventricular and interventricular dyssynchrony. The correlations between TPM velocities, myocardial structure\/function, and clinical variables were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Test<\/jats:title><jats:p>Unpaired <jats:italic>t<\/jats:italic>\u2010test, Wilcoxon rank\u2010sum test, Bland\u2013Altman analyses were used for comparisons between DMD patients and controls and between DMD subgroups. Pearson's test was used for correlations (<jats:italic>r<\/jats:italic>). Significance level: <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, DMD patients had preserved RV ejection fraction (RVEF 53%\u2009\u00b1\u20098%) but significantly increased interventricular dyssynchrony (V<jats:bold>\u03c6<\/jats:bold>: 0.49\u2009\u00b1\u20090.21 vs. 0.72\u2009\u00b1\u20090.17). Within the DMD cohort, RV dyssynchrony significantly increased with lower LV ejection fraction (intraventricular Vr and Vz: <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.49; interventricular Vz: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.48). In addition, RV intraventricular dyssynchrony significantly increased with older age (Vz: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.67).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>RV remodeling in DMD occurs in the context of preserved RVEF. Within DMD, this abnormal RV deformation is associated with older age and decreased LVEF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28521","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T13:06:59Z","timestamp":1668085619000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Right Ventricular Remodeling Assessed by <scp>MRI<\/scp> in Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-0449","authenticated-orcid":false,"given":"Nicholas K.","family":"Brown","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Pediatrics, Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haben","family":"Berhane","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University, Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katheryn","family":"Gambetta","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics Ann &amp; Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University, Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Department of Biomedical Engineering Northwestern University McCormick School of Engineering  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-2333","authenticated-orcid":false,"given":"Cynthia K.","family":"Rigsby","sequence":"additional","affiliation":[{"name":"Department of Radiology Northwestern University, Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Department of Radiology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2129-5501","authenticated-orcid":false,"given":"Joshua D.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics Ann &amp; Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazia","family":"Husain","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics Ann &amp; Robert H. 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