{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:53:08Z","timestamp":1790009588624,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771793"],"award-info":[{"award-number":["81771793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Increasing evidence has indicated that the entire visual pathway from retina to visual cortex may be involved in dysthyroid optic neuropathy (DON) pathological mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the functional and morphological brain characteristics in DON and their relationship with ophthalmologic performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 30 DON patients, 40 thyroid\u2010associated ophthalmopathy (<jats:styled-content style=\"fixed-case\">TAO<\/jats:styled-content>) without <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> patients and 21 healthy\u2010controls (<jats:styled-content style=\"fixed-case\">HCs<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A 3.0\u2009T, 3D <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content>\u2010weighted spoiled gradient\u2010recalled echo and gradient\u2010recalled echo\u2010planar imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Functional and structural alterations in brain regions were evaluated with fractional amplitude of low\u2010frequency fluctuations, degree centrality (DC), and gray matter volume (GMV). Clinical activity score (CAS) is assessed across patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Test<\/jats:title><jats:p>One\u2010way analysis of variance with post hoc two sample t\u2010tests (GRF\u2010corrected, voxel level: <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.005, cluster level: <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05) and correlation analysis (significance level: <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HCs, DON patients had significantly decreased DC values in the bilateral BA17 and BA18 regions. Compared to the TAO group, DON patients had decreased GMV in the left anterior cingulate cortex, left middle frontal gyrus, left lingual gyrus, left parietal gyrus, right Rolandic operculum, left supplementary motor area, and right middle temporal gyrus. In addition, GMV in the right Rolandic operculum was significantly positively correlated with CAS (correlation coefficient: <jats:italic>r<\/jats:italic>\u00a0=\u20090.448).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>This study showed significant morphological and functional alterations in visual cortex and morphological alterations in partial default mode network regions of DON patients, which may provide insights into the mechanism of vision loss and may facilitate the diagnosis and treatment of DON.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28534","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T11:42:09Z","timestamp":1669030929000},"page":"510-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Functional and Morphological Brain Alterations in Dysthyroid Optic Neuropathy: A Combined Resting\u2010State <scp>fMRI<\/scp> and Voxel\u2010Based Morphometry Study"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-9703","authenticated-orcid":false,"given":"Hongyu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ban","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Tongji Hospital, Tongji 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