{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:16:05Z","timestamp":1774916165117,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002378"],"award-info":[{"award-number":["82002378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear which cortical regions are specific to or commonly associated with the impairments of the upper\/lower limbs and the activities of daily life (ADL) in stroke patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the relationships between MRI\u2010assessed surface\u2010based morphometry (SBM) features and motor function as well as ADL in participants with chronic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Thirty\u2010five participants with subcortical stroke more than 3\u2009months from the first\u2010onset (age: 56.44\u2009\u00b1\u20099.56\u2009years; 32 male).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>T<jats:sub>1<\/jats:sub>\u2010weighted images, 3.0 T, three\u2010dimensional fast field\u2010echo sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>FreeSurfer (6.0) was used to parcellate each hemisphere into 34 regions based on the Desikan\u2013Killiany atlas and to extract the surface area, volume, thickness, and curvature. The motor function and ADL were assessed by the Fugl\u2010Meyer Assessment for the Upper\/Lower Extremity (FMA\u2010UE\/FMA\u2010LE) and the Chinese version of the Modified Barthel Index (MBI\u2010C), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>A linear mixed\u2010effect model was applied to evaluate the relationship between the morphological features and the FMA\u2010UE, FMA\u2010LE, and MBI\u2010C. A false discovery rate corrected <jats:italic>P<\/jats:italic> value\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Correlations between the size of stroke lesion and MRI measurements did not pass the FDR correction (adjusted <jats:italic>P<\/jats:italic>\u00a0&gt;\u20090.05). SBM features in motor\u2010related and high\u2010order cognitive cortical regions showed significant correlations with FMA\u2010UE and FMA\u2010LE, respectively. Moreover, the thickness in the prefrontal cortex significantly positively correlated, while the surface area in the right supramarginal gyrus significantly negatively correlated, with both FMA\u2010UE, FMA\u2010LE, and MBI\u2010C. The thickness in the left frontal lobe significantly positively correlated with both FMA\u2010UE and MBI\u2010C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>This study's findings suggest that different hemiparetic motor\u2010related outcomes in participants with subcortical stroke which suffered a corticospinal tract\u2010related injury show specific, but also share common, associations with several cortical regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28542","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T12:11:57Z","timestamp":1669637517000},"page":"571-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>MRI<\/scp> Assessment of the Relationship Between 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