{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:43:07Z","timestamp":1780522987962,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019\u2010I2M\u20105\u2010039"],"award-info":[{"award-number":["2019\u2010I2M\u20105\u2010039"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC1398"],"award-info":[{"award-number":["2022NSFSC1398"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>How the functional interactions of the basal ganglia\/thalamus with the cerebral cortex and the cerebellum change over the adult lifespan in movie\u2010watching and resting\u2010state is less clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the functional changes in the organization of the human cortical\u2013subcortical functional networks over the adult lifespan using movie\u2010watching and resting\u2010state fMRI data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Healthy 467 adults (cross\u2010sectional individuals aged 18\u201388\u2009years) from the Cambridge Centre for Ageing and Neuroscience (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.cam-can.com\">www.cam-can.com<\/jats:ext-link>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>fMRI using a gradient\u2010echo echo\u2010planar imaging (EPI) sequence at 3\u00a0T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Functional connectivities (FCs) of the subcortical subregions (i.e. the basal ganglia and thalamus) with both the cerebral cortex and cerebellum were examined in fMRI data acquired during resting state and movie\u2010watching. And, fluid intelligence scores were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Student's <jats:italic>t<\/jats:italic>\u2010tests, false discovery rate (FDR) corrected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As age increased, FCs that mainly within the basal ganglia and thalamus, and between the basal ganglia\/thalamus and cortical networks (including the dorsal attention, ventral attention, and limbic networks) were both increased\/decreased during movie\u2010watching and resting states. However, FCs showed a state\u2010dependent component with advancing age. During the movie\u2010watching state, the FCs between the basal ganglia\/thalamus and cerebellum\/frontoparietal control networks were mainly increased with age, and the FCs in the somatomotor network were decreased with age. During the resting state, the FCs between the basal ganglia\/thalamus and default mode\/visual networks were mainly increased with age, and the FCs in the cerebellum were mainly decreased with age. Moreover, inverse relationships between FCs and fluid intelligence were mainly found in these network regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Our study may suggest that changes in cortical\u2013subcortical functional networks across the adult lifespan were both state\u2010dependent and stable traits, and that aging fMRI studies should consider the effects of both physiological characteristics and individual situations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28599","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T16:23:00Z","timestamp":1673626980000},"page":"720-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trait\u2010 and State\u2010Dependent 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