{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T21:53:18Z","timestamp":1788126798307,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 123431"],"award-info":[{"award-number":["MOP 123431"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT 153099"],"award-info":[{"award-number":["PJT 153099"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple\u2010breath washout (MBW) <jats:sup>129<\/jats:sup>Xe MRI (MBW Xe\u2010MRI) is a promising technique for following pediatric cystic fibrosis (CF) lung disease progression. However, its repeatability in stable CF needs to be established to use it as an outcome measure for novel therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess intravisit and intervisit repeatability of MBW Xe\u2010MRI in healthy and CF children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective, longitudinal cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>A total of 18 pediatric subjects (7 healthy, 11 CF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A 3\u2009T\/2D coronal hyperpolarized (HP) <jats:sup>129<\/jats:sup>Xe images using GRE sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>All subjects completed MBW Xe\u2010MRI, pulmonary function tests (PFTs) (spirometry, nitrogen [N<jats:sub>2<\/jats:sub>] MBW for lung clearance index [LCI]) and ventilation defect percent (VDP) at baseline (visit 1) and 1\u2010month after. Fractional ventilation (FV), coefficient of variation (CoV<jats:sub>FV<\/jats:sub>) maps were calculated from MBW Xe\u2010MRI data acquired between intervening air washout breaths performed after an initial xenon breath\u2010hold. Skewness of FV and CoV<jats:sub>FV<\/jats:sub> map distributions was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Repeatability: intraclass correlation coefficients (ICC), within\u2010subject coefficient of variation (CV%), repeatability coefficient (CR). Agreement: Bland\u2013Altman. For correlations between MBW Xe\u2010MRI, VDP and PFTs: Spearman's correlation. Significance threshold: <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For FV, intravisit median [IQR] ICC was high in both healthy (0.94 [0.48, 0.99]) and CF (0.83 [0.04, 0.97]) subjects. CoV<jats:sub>FV<\/jats:sub> also had good intravisit ICC in healthy (0.92 [0.42, 0.99]) and CF (0.79 [0.02, 0.96]) subjects. Similarly, for FV, intervisit ICC was high in health (0.94 [0.68, 0.99]) and CF (0.89 [0.61, 0.97]). CoV<jats:sub>FV<\/jats:sub> also had good intervisit ICC in health (0.92 [0.42, 0.99]) and CF (0.78 [0.26, 0.94]). FV had better intervisit repeatability than VDP. CoV<jats:sub>FV<\/jats:sub> correlated significantly with LCI (<jats:italic>R<\/jats:italic>\u00a0=\u00a00.56). Skewness of FV distributions significantly distinguished between cohorts at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>MBW Xe\u2010MRI had high intravisit and intervisit repeatability in healthy and stable CF subjects. CoV<jats:sub>FV<\/jats:sub> correlated with LCI, suggesting the importance of ventilation heterogeneity to early CF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28638","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:14:22Z","timestamp":1676384062000},"page":"936-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Intra<scp>\u2010<\/scp> and <scp>Inter\u2010visit<\/scp> Repeatability of <scp><sup>129<\/sup>Xenon Multiple\u2010Breath<\/scp> Washout <scp>MRI<\/scp> in Children With Stable Cystic Fibrosis Lung Disease"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-7536","authenticated-orcid":false,"given":"Faiyza 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