{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:13:20Z","timestamp":1792750400432,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:00:00Z","timestamp":1676073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SCU2020D4132"],"award-info":[{"award-number":["SCU2020D4132"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771897"],"award-info":[{"award-number":["81771897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971586"],"award-info":[{"award-number":["81971586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071874"],"award-info":[{"award-number":["82071874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8177188"],"award-info":[{"award-number":["8177188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901712"],"award-info":[{"award-number":["81901712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271981"],"award-info":[{"award-number":["82271981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      High\u2010speed T\n                      <jats:sub>2<\/jats:sub>\n                      \u2010corrected multiecho MRS (HISTO\u2010MRS) is emerging as a quantitative modality for detecting muscle fat infiltration (MFF). However, the predictive value of HISTO\u2010MRS for the loss of ambulation (LoA) in Duchenne muscular dystrophy (DMD) is unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the feasibility of HISTO\u2010MRS for assessing MFF in DMD and further identify the predictive value of HISTO\u2010MRS for the LoA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>A total of 134 DMD boys (9.20\u2009\u00b1\u20092.43\u2009years old) and 21 healthy boys (9.25\u2009\u00b1\u20092.10\u2009years old).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>\n                      A 3\u2009T, fast spin echo T\n                      <jats:sub>1<\/jats:sub>\n                      \u2010weighted imaging (T\n                      <jats:sub>1<\/jats:sub>\n                      WI), two\u2010point\u2010Dixon gradient echo sequence (2\u2010pt\u2010Dixon) and HISTO\u2010MRS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>\n                      Subjective T\n                      <jats:sub>1<\/jats:sub>\n                      WI fat grades by three radiologists, ROI analysis for MFF on 2\u00a0pt\u2010Dixon (Dixon MFF) and MFF on HISTO\u2010MRS (HISTO MFF) by two radiologists. Clinical motor function: North Star Ambulatory Assessment, 10\u2010m run\/walk time, Gowers maneuver, and time to four\u2010stairs climb and descend.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Spearman rank correlation was used to assess the relation of fat filtration assessments and motor ability. Bland\u2013Altman plots was performed to determine the agreement of HISTO MFF and Dixon MFF. Receiver operating characteristic (ROC) curves were analyzed to determine the discriminating ability of above MRI modalities for ambulatory and nonambulatory DMD. Logistic regression was used to identify the predictor of LoA. Variables with\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05 in univariate logistic regression analysis were entered into the multivariate logistic regression model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HISTO MFF was significantly correlated with Dixon MFF. Bland\u2013Altman plots show good agreement of HISTO MFF and Dixon MFF. ROC curves indicated that HISTO MFF show similar discrimination of LoA for DMD with Dixon MFF but better value than T1WI fat grades. Logistic regression showed that HISTO MFF was an independent predictor for LoA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>HISTO\u2010MRS is a potential quantitative method for assessing fat infiltration and shows predictive value for LoA in DMD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 5.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.28641","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T10:04:44Z","timestamp":1676109884000},"page":"1270-1278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["High\u2010Speed\n                    <scp>\n                      T\n                      <sub>2<\/sub>\n                    <\/scp>\n                    \u2010Corrected Multiecho Magnetic Resonance Spectroscopy for Quantitatively Detecting Skeletal Muscle Fatty Infiltration and Predicting the Loss of Ambulation in Patients With Duchenne Muscular Dystrophy"],"prefix":"10.1002","volume":"58","author":[{"given":"Ting","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiology Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University  Wuhou District Chengdu 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