{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:32:15Z","timestamp":1792416735928,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171918"],"award-info":[{"award-number":["82171918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1908211"],"award-info":[{"award-number":["U1908211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anthracyclines are known to be associated with chemotherapy\u2010induced cardiotoxicity. Limited data focus on dynamic myocardial injury during the course of chemotherapy in patients with breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the variation of tissue characterization and myocardial deformation derived by cardiac MRI during anthracycline chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Fifty\u2010eight female breast cancer patients (mean age: 52.82\u2009\u00b1\u20092.61\u2009years) were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A 3.<jats:styled-content style=\"fixed-case\">0\u2010T<\/jats:styled-content>, cardiac <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> including cine balanced steady\u2010state free precession, a modified <jats:styled-content style=\"fixed-case\">Looker\u2010Locker<\/jats:styled-content> inversion recovery (<jats:styled-content style=\"fixed-case\">MOLLI<\/jats:styled-content>), and a fast spin echo (<jats:styled-content style=\"fixed-case\">FSE<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\u2010weighted sequences were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Cardiac MRI was performed baseline and after two, four, and six\u2009cycles of chemotherapy. Assessment of global longitudinal strain (GLS), global circumstance strain (GCS), global radial strain (GRS), and strain rate (GLS\u2010s, GCS\u2010s, GRS\u2010s) and T1, T2 and T2* were accomplished by CVI42. The anthracycline dose and risk factors were also collected before each cardiac MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Analysis of variance (ANOVA) for repeated measures was used to compare the changes in LVEF cardiac function, strain and T1\/T2\/T2* parameters over time. Pearson correlation analyses were performed to estimate the potential associations between differences in myocardial characteristics (\u2206) and the chemotherapy cycle. A <jats:italic>P<\/jats:italic> value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LVEF was not significantly different from pretreatment MRI regarding each cycle of chemotherapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.54). Compared with baseline, patients had significantly lower GLS (\u221215.85%\u2009\u00b1\u20090.83%, \u221214.50%\u2009\u00b1\u20090.88%, \u221212.34%\u2009\u00b1\u20091.01% vs. \u201318.82%\u2009\u00b1\u20090.92%) and GLS\u2010s (\u22120.71%\u2009\u00b1\u20090.07%, \u22120.65%\u2009\u00b1\u20090.05%, \u22120.64%\u2009\u00b1\u20090.04% vs. \u20130.95\u2009\u00b1\u20090.06%) and increased T2 values (57.21\u2009\u00b1\u20094.27\u2009msec, 58.60\u2009\u00b1\u20093.93\u2009msec, 58.10\u2009\u00b1\u20093.17\u2009msec vs. 43.88\u2009\u00b1\u20093.28\u2009msec) at two, four and six\u2009cycles of chemotherapy treatment. \u2206GLS and \u2206GLS\u2010s were significantly associated with the chemotherapy cycle (correlation coefficients for GLS\u00a0=\u00a00.75, GLS\u2010s\u00a0=\u00a00.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Cardiac MRI can precisely detect the dynamic changes of anthracycline\u2010induced subclinical myocardial injury that is represented as a gradually decrease in GLS and GLS\u2010s. These parameters may provide new insight for monitoring risk and therapy in patients with breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 1.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28667","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T11:44:23Z","timestamp":1678707863000},"page":"1533-1541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serial Cardiac <scp>MRI<\/scp> for Quantification of the Dynamics of Anthracycline\u2010Induced Subclinical Myocardial Injury"],"prefix":"10.1002","volume":"58","author":[{"given":"Yue","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibi","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetong","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Cancer Hospital of China Medical University  Shenyang China"},{"name":"Department of Breast Surgery Liaoning Cancer Hospital &amp; Institute  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0672-796X","authenticated-orcid":false,"given":"Shiqi","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiology Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"},{"name":"Liaoning University of Traditional Chinese Medicine  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0516-6996","authenticated-orcid":false,"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Cancer Hospital of China Medical University  Shenyang China"},{"name":"Department of Breast Surgery Liaoning Cancer Hospital &amp; Institute  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.5400"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.07.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-018-4779-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw671"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13365"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-018-1009-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31674-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019811"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-10028-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.01.034"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018181039"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.03.041"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0260-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-022-00881-1"},{"issue":"53","key":"e_1_2_8_18_1","first-page":"1","article-title":"Myocardial T1 and T2 mapping at 3 T: Reference values, influencing factors and implications","volume":"15","author":"Florian von Knobelsdorff\u2010Brenkenhoff MP","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25520"},{"issue":"4","key":"e_1_2_8_20_1","first-page":"392","article-title":"Assessment of global longitudinal strain at low\u2010dose anthracycline\u2010based chemotherapy, for the prediction of subsequent cardiotoxicity","volume":"18","author":"Charbonnel C","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.02.008"},{"issue":"2","key":"e_1_2_8_22_1","first-page":"140","article-title":"Global longitudinal strain accuracy for cardiotoxicity prediction in a cohort of breast cancer patients during Anthracycline and\/or Trastuzumab treatment","volume":"110","author":"Gripp EA","year":"2018","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.12.022"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002217"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.121.012459"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0373-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015400"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.048"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14252"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.017"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.04.007"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.020"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307974"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.10.016"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.05.012"},{"key":"e_1_2_8_36_1","first-page":"2175","article-title":"Anthracycline and trastuzumab\u2010induced cardiotoxicity in breast cancer","volume":"22","author":"Nicolazzi Ac MA","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.12.027"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003584"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-021-00767-8"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111769"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.28667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.28667","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.28667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:20:49Z","timestamp":1698729649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.28667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/jmri.28667"],"URL":"https:\/\/doi.org\/10.1002\/jmri.28667","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"assertion":[{"value":"2022-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}