{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:20:24Z","timestamp":1774308024888,"version":"3.50.1"},"reference-count":72,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Peliosis hepatis (PH) is a rare benign condition, characterized by hepatic sinusoidal dilatation and blood\u2010filled cystic cavities, often found incidentally, with still challenging diagnosis by imaging due to polymorphic appearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Based on a retrospective analysis of our series (12 patients) and systematic literature review (1990\u20132022), to organize data about PH and identify features to improve characterization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective case series and systematic review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Twelve patients (mean age 48\u2009years, 55% female) with pathology\u2010proven PH and 49 patients (mean age 52\u2009years, 67% female) identified in 33 studies from the literature (1990\u20132022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">1,5\u2010T<\/jats:styled-content>; <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content>\u2010weighted (<jats:styled-content style=\"fixed-case\">T1W<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\u2010weighted (<jats:styled-content style=\"fixed-case\">T2W<\/jats:styled-content>), diffusion\u2010weighted (<jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>), contrast\u2010enhanced (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">T1W<\/jats:styled-content> imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>We compared our series and literature data in terms of demographic (gender\/age\/ethnicity), clinical characteristics (symptoms\/physical examination\/liver test), associated conditions (malignancies\/infectious\/hematologic\/genetic or chronic disorders\/drugs or toxic exposure) percentage. On magnetic resonance imaging lesion numbers\/shape\/mean maximum diameter\/location\/mass effect\/signal intensity were compared. PH pathological type\/proposed imaging diagnosis\/patient follow\u2010up were also considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports\/Series quality assessment. Intraclass correlation and Cohen's kappa coefficients for levels of inter\/intrareader agreement in our experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were mainly asymptomatic (92% vs. 70% in our study and literature) with associated conditions (83% vs. 80%). Lesions showed homogeneous T1W\u2010hypointensity (58% vs. 65%) and T2W\u2010hyperintensity (58% vs. 66%). Heterogeneous nonspecific (25% vs. 51%), centrifugal (34% vs. 8%), or rim\u2010like centripetal (25% vs. 23%) patterns of enhancement were most frequent, with hypointensity on the hepatobiliary phase (HBP), without restricted diffusivity. Good inter\u2010 and intrareader agreement was observed in our experience. Concerning JBI Checklist, 19 out of 31 case reports met at least 7 out of 8 criteria, whereas 2 case series fulfilled 5 and 6 out of 10 items respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>A homogeneous, not well\u2010demarcated T1W\u2010hypointense and T2W\u2010hyperintense mass, with heterogeneous nonspecific or rim\u2010like centripetal or centrifugal pattern of enhancement, and hypointensity on HBP, may be helpful for PH diagnosis. Among associated conditions, malignancies and drug exposures were the most frequent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28673","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T14:41:49Z","timestamp":1680100909000},"page":"1386-1405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>MRI<\/scp> of Peliosis Hepatis: A Case Series Presentation With a 2022 Systematic Literature Update"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-4820","authenticated-orcid":false,"given":"Linda","family":"Calistri","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2 University of Florence, Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5489-7824","authenticated-orcid":false,"given":"Cosimo","family":"Nardi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2 University of Florence, Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-5305","authenticated-orcid":false,"given":"Vieri","family":"Rastrelli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2 University of Florence, Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-5470","authenticated-orcid":false,"given":"Davide","family":"Maraghelli","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2 University of Florence, Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-1571","authenticated-orcid":false,"given":"Luigi","family":"Grazioli","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Brescia \u201cSpedali Civili\u201d  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Messerini","sequence":"additional","affiliation":[{"name":"Department of Human Pathology and Oncology University of Florence, Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0137-8606","authenticated-orcid":false,"given":"Stefano","family":"Colagrande","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2 University of Florence, Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Peliosis hepatis","volume":"26","author":"Zak FG","year":"1950","journal-title":"Am J Pathol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2015.21.4.387"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i46.13188"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2004.05.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2004.11679652"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.12.008"},{"key":"e_1_2_6_8_1","first-page":"159","article-title":"An anatomic study with demonstration of two varieties","volume":"77","author":"Yanoff M","year":"1964","journal-title":"Arch Pathol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0167"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.20162"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-001-0023-x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050691"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.26397"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61539-5"},{"key":"e_1_2_6_15_1","first-page":"41","article-title":"Generalised peliosis hepatis mimicking metastases after long\u2010term use of oral contraceptives","volume":"73","author":"Kootte AM","year":"2015","journal-title":"Neth J Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(03)00141-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.185.2.01850558"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1675-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2017160161"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-01941-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02107904"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-7-16"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-20-08"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBISRIR-D-19-00099"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rct.0000232919.22287.20"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-8153"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0720-048X(93)90073-V"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.158.1.1727362"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02020839"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1998.17.9.581"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002610000131"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-1852-5"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.029"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i41.5999"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i16.2578"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12031"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-200539"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.050"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0682-9"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4286"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13237"},{"key":"e_1_2_6_43_1","first-page":"1","article-title":"Peliosis hepatis simulates liver metastases","volume":"4","author":"Zucchetti BM","year":"2018","journal-title":"J Glob Oncol"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006471"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.2017.21.3.157"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.14740\/gr873e"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.02.032"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018141"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X20931996"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-019-01068-5"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2020.04.059"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002114"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-014-0281-5"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31179-2"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2014.12.030"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.156.1.1845436"},{"key":"e_1_2_6_57_1","first-page":"419","article-title":"Peliosis hepatis in a child","volume":"100","author":"Usatin MS","year":"1976","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.8.748"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e31811ec6d4"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2017.18.3.413"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i46.7866"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110225"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.02.011"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i17.2012"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-008-0035-9"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12565"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-022-03555-9"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2007.03.003"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-011-0624-4"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/374170"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21684"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12636"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8951"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.28673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:19:58Z","timestamp":1698729598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.28673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/jmri.28673"],"URL":"https:\/\/doi.org\/10.1002\/jmri.28673","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,29]]},"assertion":[{"value":"2022-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}