{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:01:25Z","timestamp":1793505685640,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015650","name":"Canon Medical Systems Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015650","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Amide proton transfer (APT) weighted chemical exchange saturation transfer CEST (APTw\/CEST) magnetic resonance imaging (MRI) has been suggested as having the potential for assessing the therapeutic effect of brain tumors or rectal cancer. Moreover, diffusion\u2010weighted imaging (DWI) and positron emission tomography fused with computed tomography by means of 2\u2010[fluorine\u201018]\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose (FDG\u2010PET\/CT) have been suggested as useful in same setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the capability of APTw\/CEST imaging, DWI, and FDG\u2010PET\/CT for predicting therapeutic effect of chemoradiotherapy (CRT) on stage III non\u2010small cell lung cancer (NSCLC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eighty\u2010four consecutive patients with Stage III NSCLC, 45 men (age range, 62\u201375\u2009years; mean age, 71\u2009years) and 39 women (age range, 57\u201375\u2009years; mean age, 70\u2009years). All patients were then divided into two groups (Response Evaluation Criteria in Solid Tumors [RECIST] responders, consisting of the complete response and partial response groups, and RECIST non\u2010responders, consisting of the stable disease and progressive disease groups).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3\u2009T, echo planar imaging or fast advanced spin\u2010echo (FASE) sequences for DWI and 2D half Fourier FASE sequences with magnetization transfer pulses for CEST imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Magnetization transfer ratio asymmetry (MTR<jats:sub>asym<\/jats:sub>) at 3.5\u2009ppm, apparent diffusion coefficient (ADC), and maximum standard uptake value (SUV<jats:sub>max,<\/jats:sub>) on PET\/CT were assessed by means of region of interest (ROI) measurements at primary tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Kaplan\u2013Meier method followed by log\u2010rank test and Cox proportional hazards regression analysis with multivariate analysis. A <jats:italic>P<\/jats:italic> value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Progression\u2010free survival (PFS) and overall survival (OS) had significant difference between two groups. MTR<jats:sub>asym<\/jats:sub> at 3.5\u2009ppm (hazard ratio [HR]\u2009=\u20090.70) and SUV<jats:sub>max<\/jats:sub> (HR\u2009=\u20091.41) were identified as significant predictors for PFS. Tumor staging (HR\u2009=\u20090.57) was also significant predictors for OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>APTw\/CEST imaging showed potential performance as DWI and FDG\u2010PET\/CT for predicting the therapeutic effect of CRT on stage III NSCLC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 1<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28691","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T13:24:40Z","timestamp":1679923480000},"page":"174-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Chemical Exchange Saturation Transfer <scp>MRI<\/scp>: Capability for Predicting Therapeutic Effect of Chemoradiotherapy on Non\u2010Small Cell Lung Cancer 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