{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:31:00Z","timestamp":1778355060446,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171918"],"award-info":[{"award-number":["82171918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There are known cardiac manifestations of HIV, but the findings in asymptomatic subjects are still not fully explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate for the presence of subclinical myocardial injury in asymptomatic people living with human immunodeficiency virus (PLWH) by cardiac MRI and to explore the possible association between subclinical myocardial injury and HIV\u2010related clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Cross\u2010sectional.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>A total of 80 asymptomatic PLWH (age: 53\u2009years [47\u201356\u2009years]; 90% male) and 50 age\u2010 and sex\u2010matched healthy participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>A 3\u2010T, cine sequence, T1, T2, and T2* mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Function analysis was derived from short axis, two\u2010, three\u2010, and four\u2010chamber cine images by feature tracking. Regions of interest were manually selected in the midventricular septum T1, T2, and T2* mapping sequences. PLWH were evaluated for T1 increment (\u25b3T1 mapping\u2009=\u2009native T1\u2009\u2212\u2009cutoff values) and HIV\u2010related clinical characteristics, particularly the nadir CD4 count. And PLWH were stratified into two groups according to the cutoff value of native T1: elevated native T1 and normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p><jats:italic>T<\/jats:italic> test, Wilcoxon rank\u2010sum test, Chi\u2010square test, Spearman rank correlation, and logistic regression. <jats:italic>P<\/jats:italic>\u2009&lt;0.05 indicated statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Asymptomatic PLWH revealed significantly higher native myocardial T1 values (1241\u2009\u00b1\u200929\u2009msec vs. 1189\u2009\u00b1\u200921\u2009msec), T2 values (40.7\u2009\u00b1\u20091.5\u2009msec vs. 37.9\u2009\u00b1\u20091.4\u2009msec), and lower LVGRS (30.2%\u2009\u00b1\u20096.2% vs. 35.8%\u2009\u00b1\u20096.4%), LVGCS (\u221218.0%\u2009\u00b1\u20092.5% vs. \u221219.5%\u2009\u00b1\u20092.0%), and LVGLS (\u221216.0%\u2009\u00b1\u20093.8% vs. \u221217.9%\u2009\u00b1\u20092.6%) but showed no difference in T2* values (17.3\u2009msec [16.3\u201319.1\u2009msec] vs. 18.3\u2009msec [16.5\u201319.3\u2009msec], <jats:italic>P<\/jats:italic>\u2009=\u20090.201). A negative correlation between the native T1 increment in PLWH with subclinical myocardial injury and the nadir CD4 count (u\u2009=\u2009\u22120.316). Nadir CD4 count &lt;500 cells\/mm<jats:sup>3<\/jats:sup> was associated with higher odds of elevated native T1 myocardial values (odds ratio, 6.12 [95% CI, 1.07\u201334.91]) in PLWH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Subclinical myocardial inflammation and dysfunction were present in asymptomatic PLWH, and a lower nadir CD4 count may be a risk factor for subclinical myocardial injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28699","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T14:59:30Z","timestamp":1680101970000},"page":"1815-1823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac <scp>MRI<\/scp>\u2010Based Assessment of Myocardial Injury in Asymptomatic People Living With Human Immunodeficiency Virus: Correlation With nadir <scp>CD4<\/scp> Count"],"prefix":"10.1002","volume":"58","author":[{"given":"Xin","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Radiology The First Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Ding","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine The First Hospital of China Medical University  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology Chinese Academy of Medical Sciences  Shenyang China"},{"name":"Key Laboratory of AIDS Immunology of Liaoning Province  Shenyang China"},{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases  Hangzhou 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