{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:01:53Z","timestamp":1787868113896,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T00:00:00Z","timestamp":1682726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61936103"],"award-info":[{"award-number":["61936103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271963"],"award-info":[{"award-number":["82271963"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2023,12]]},"abstract":"Background<\/jats:title>The combination of radiomics and diffusion tensor imaging (DTI) may have potential clinical value in the early stage of HIV\u2010associated neurocognitive disorders (HAND).<\/jats:p><\/jats:sec>Purpose<\/jats:title>To investigate the value of DTI\u2010based radiomics in the early stage of HAND in people living with HIV (PLWH).<\/jats:p><\/jats:sec>Study Type<\/jats:title>Retrospective.<\/jats:p><\/jats:sec>Population<\/jats:title>A total of 138 male PLWH were included, including 68 with intact cognition (IC) and 70 with asymptomatic neurocognitive impairment (ANI). Seventy healthy controls (HCs) were recruited for tract\u2010based spatial statistics (TBSS) analysis. All PLWHs were randomly divided into training and validation cohorts at a 7:3 ratio.<\/jats:p><\/jats:sec>Field Strength\/Sequence<\/jats:title>A 3\u2009T, single\u2010shot spin\u2013echo echo planar imaging (EPI).<\/jats:p><\/jats:sec>Assessment<\/jats:title>The differences between the PLWH groups were compared using TBSS and region of interest (ROI) analysis. Radiomic features were extracted from the corpus callosum (CC) on DTI postprocessed images, including fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD). The performance of the radiomic signatures was evaluated by ROC curve analysis. The radiomic signature with the highest area under the curve (AUC) was combined with clinical characteristics to construct a nomogram. Decision curve analysis (DCA) was performed to evaluate the ability of different methods in discriminating ANI.<\/jats:p><\/jats:sec>Statistical Tests<\/jats:title>Chi\u2010square test, independent\u2010samples t<\/jats:italic> test, Kruskal\u2013Wallis test, Mann\u2013Whitney U test, threshold\u2010free cluster enhancement (TFCE), ROC curve analysis, DCA, multivariate logistic regression analysis, Hosmer\u2013Lemeshow test. P<\/jats:italic>\u2009<\u20090.05 with TFCE corrected and P<\/jats:italic>\u2009<\u20090.0001 without TFCE corrected were considered statistically significant.<\/jats:p><\/jats:sec>Results<\/jats:title>The ANI group showed lower FA and higher AD than the IC group. In the validation cohort, the AUCs of the FA\u2010, AD\u2010, MD\u2010 and RD\u2010based radiomic signatures and the clinicoradiomic nomogram were 0.829, 0.779, 0.790, 0.864, and 0.874, respectively. DCA revealed that the nomogram was of greater clinical value than TBSS analysis, the clinical models, and the RD\u2010based radiomic signature.<\/jats:p><\/jats:sec>Data Conclusion<\/jats:title>The combination of DTI and radiomics is correlated with early stage of HAND in PLWH.<\/jats:p><\/jats:sec>Evidence Level<\/jats:title>3.<\/jats:p><\/jats:sec>Technical Efficacy<\/jats:title>Stage 2.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28741","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T07:24:16Z","timestamp":1682753056000},"page":"1882-1891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Value of Radiomic Analysis Combined With Diffusion Tensor Imaging in Early Diagnosis of HIV<\/scp>\u2010Associated Neurocognitive Disorders"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2204-1420","authenticated-orcid":false,"given":"Yu","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing China"},{"name":"Institute of Medical Imaging and Artificial Intelligence Nanjing University Nanjing China"},{"name":"Medical Imaging Center, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-0559","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Rehabilitation Medicine, Department of Psychiatry, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College) Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine) Hangzhou China"},{"name":"The First School of Clinical Medicine Zhejiang Chinese Medical University Hangzhou 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