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However, MRI LSA evaluation at 3T is challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate middle cerebral artery (MCA) plaque characteristics and LSA morphology associated with subcortical infarctions in LSA territories using 7\u2010T vessel wall MRI (VW\u2010MRI) and time\u2010of\u2010flight MR angiography (TOF\u2010MRA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Sixty patients with 80 MCA atherosclerotic plaques (37 culprit and 43 non\u2010culprit).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>7\u2010T with 3D TOF\u2010MRA and T1\u2010weighted 3D sampling perfection with application\u2010optimized contrast using different flip angle evolutions (SPACE) sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Plaque distribution (superior, inferior, ventral, or dorsal walls), LSA origin involvement, LSA morphology (numbers of stems, branches, and length), and plaque characteristics (normalized wall index, maximal wall thickness, plaque length, remodeling index, intraplaque hemorrhage, and plaque surface morphology (regular or irregular)) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Least absolute shrinkage and selection operator regression, generalized estimating equations regression, receiver operating characteristic curve, independent <jats:italic>t<\/jats:italic>\u2010test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, Chi\u2010square test, Fisher's exact test, and intra\u2010class coefficient. A <jats:italic>P<\/jats:italic> value &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plaque irregular surface, superior wall plaque, longer plaque length, LSA origin involvement, fewer LSA stems, and shorter total and average lengths of LSAs were significantly associated with culprit plaques. Multivariable logistic analysis confirmed that LSA origin involvement (OR, 28.51; 95% CI, 6.34\u2013181.02) and plaque irregular surface (OR, 8.32; 95% CI, 1.41\u201364.73) were independent predictors in differentiating culprit from non\u2010culprit plaques. A combination of LSA origin involvement and plaque irregular surface (area under curve\u2009=\u20090.92; [95% CI, 0.86\u20130.98]) showed good performance in identifying culprit plaques, with sensitivity and specificity of 86.5% and 86.0%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>7\u2010T VW\u2010MRI and TOF\u2010MRA can demonstrate plaque involvement with LSA origins. MCA plaque characteristics derived from 7\u2010T VW\u2010MRI showed good diagnostic accuracy in determining the occurrence of subcortical infarctions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>2<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28839","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T09:51:04Z","timestamp":1685613064000},"page":"1045-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluating Middle Cerebral Artery Plaque Characteristics and Lenticulostriate Artery Morphology Associated With Subcortical Infarctions at <scp>7T MRI<\/scp>"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0697-4378","authenticated-orcid":false,"given":"Xiaoyan","family":"Bai","sequence":"first","affiliation":[{"name":"Tiantan Neuroimaging Center for Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Department of Radiology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Fan","sequence":"additional","affiliation":[{"name":"Tiantan Neuroimaging Center for Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Department of Radiology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiye","family":"Li","sequence":"additional","affiliation":[{"name":"Tiantan Neuroimaging Center for Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Department of Radiology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmud","family":"Mossa\u2010Basha","sequence":"additional","affiliation":[{"name":"Department of Radiology University of North Carolina  Chapel Hill North Carolina USA"},{"name":"Department of Radiology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingle","family":"Kong","sequence":"additional","affiliation":[{"name":"MR Collaboration, Siemens Healthineers Ltd.  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