{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:52Z","timestamp":1772118712044,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012019","name":"Fondation du Souffle","doi-asserted-by":"publisher","award":["Laur\u00e9at 2021"],"award-info":[{"award-number":["Laur\u00e9at 2021"]}],"id":[{"id":"10.13039\/100012019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients is associated with severe lung damage and requires specific therapeutic management. Repeated imaging is recommended to both diagnose and follow\u2010up response to treatment of ABPA in CF. However, high risk of cumulative radiation exposure requires evaluation of free\u2010radiation techniques in the follow\u2010up of CF patients with ABPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate whether Fourier decomposition (FD) functional lung MRI can detect response to treatment of ABPA in CF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective longitudinal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Twelve patients (7M, median\u2010age:14\u2009years) with CF and ABPA with pre\u2010 and post\u2010treatment MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>2D\u2010balanced\u2010steady\u2010state free\u2010precession (bSSFP) sequence with FD at 1.5T.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Ventilation\u2010weighted (V) and perfusion\u2010weighted (Q) maps were obtained after FD processing of 2D\u2010coronal bSSFP time\u2010resolved images acquired before and 3\u20139\u2009months after treatment. Defects extent was assessed on the functional maps using a qualitative semi\u2010quantitative score (0\u2009=\u2009absence\/negligible, 1\u2009=\u2009&lt;50%, 2\u2009=\u2009&gt;50%). Mean and coefficient of variation (CV) of the ventilation signal\u2010intensity (VSI) and the perfusion signal\u2010intensity (QSI) were calculated. Measurements were performed independently by three readers and averaged. Inter\u2010reader reproducibility of the measurements was assessed. Pulmonary function tests (PFTs) were performed within 1\u2009week of both MRI studies as markers of the airflow\u2010limitation severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Comparisons of medians were performed using the paired Wilcoxon\u2010test. Reproducibility was assessed using intraclass correlation coefficient (ICC). Correlations between MRI and PFT parameters were assessed using the Spearman\u2010test (rho correlation\u2010coefficient). A\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value &lt;0.05 was considered as significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Defects extent on both V and Q maps showed a significant reduction after ABPA treatment (4.25 vs. 1.92 for V\u2010defect\u2010score and 5 vs. 2.75 for Q\u2010defect\u2010score). VSI_mean was significantly increased after treatment (280 vs. 167). Qualitative analyses reproducibility showed an ICC\u2009&gt;\u20090.90, while the ICCs of the quantitative measurements was almost perfect (&gt;0.99). Changes in VSI_cv and QSI_cv before and after treatment correlated inversely with changes of FEV1%p (rho\u2009=\u2009\u22120.68 for both).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>Non\u2010contrast\u2010enhanced FD lung MRI has potential to reproducibly assess response to treatment of ABPA in CF patients and correlates with PFT obstructive parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>4<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 3<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.28844","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T11:21:13Z","timestamp":1685704873000},"page":"909-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Non\u2010Contrast\u2010Enhanced Functional Lung\n                    <scp>MRI<\/scp>\n                    to Evaluate Treatment Response of Allergic Bronchopulmonary Aspergillosis in Patients With Cystic Fibrosis: A Pilot Study"],"prefix":"10.1002","volume":"59","author":[{"given":"Ilyes","family":"Benlala","sequence":"first","affiliation":[{"name":"Department of Radiology University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) Member of the German Center for Lung Research (DZL)  Munich Germany"},{"name":"Univ. Bordeaux Centre de Recherche Cardio\u2010thoracique de Bordeaux  Pessac France"},{"name":"CHU Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires Service d'Exploration Fonctionnelle Respiratoire, Unit\u00e9 de Pneumologie P\u00e9diatrique, CIC 1401  Pessac France"},{"name":"INSERM U1045, Centre de Recherche Cardio\u2010thoracique de Bordeaux  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabea","family":"Klaar","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) Member of the German Center for Lung Research (DZL)  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gaass","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Pneumology Center (CPC\u2010M) Member of the German Center for Lung Research (DZL)  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Macey","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires Service d'Exploration Fonctionnelle Respiratoire, Unit\u00e9 de Pneumologie P\u00e9diatrique, CIC 1401  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Bui","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires Service d'Exploration Fonctionnelle Respiratoire, Unit\u00e9 de Pneumologie P\u00e9diatrique, CIC 1401  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baudouin Denis De","family":"Senneville","sequence":"additional","affiliation":[{"name":"Mathematical Institute of Bordeaux (IMB) Univ. 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