{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:20:59Z","timestamp":1792693259153,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The assessment of resectability after neoadjuvant chemotherapy of hepatoblastoma is dependent on Post\u2010Treatment EXTENT of Disease (POSTTEXT) staging and its annotation factors P (portal venous involvement) and V (hepatic venous\/inferior vena cava [IVC] involvement), but MR performance in assessing them remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the diagnostic performance of contrast\u2010enhanced MR imaging for preoperative POSTTEXT staging and diagnosing vascular involvement in terms of annotation factors P and V in pediatric hepatoblastoma following neoadjuvant chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Thirty\u2010five consecutive patients (17 males, median age, 24\u2009months; age range, 6\u201398\u2009months) with proven hepatoblastoma underwent preoperative MR imaging following neoadjuvant chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>3.0 T; <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\u2010weighted imaging (<jats:styled-content style=\"fixed-case\">T2WI<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">T2WI<\/jats:styled-content> with fat suppression, diffusion weighted imaging, radial stack\u2010of\u2010the\u2010star\/Cartesian <jats:styled-content style=\"fixed-case\">3D<\/jats:styled-content> Dixon <jats:styled-content style=\"fixed-case\">T1<\/jats:styled-content>\u2010weighted gradient echo imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>Three radiologists independently assessed the POSTTEXT stages and annotation factors P and V based on the 2017 PRE\/POSTTEXT system. The sensitivities and specificities were calculated for 1) diagnosing each POSTTEXT stage; 2) discrimination of stages III and IV (advanced) from those stages I and II (non\u2010advanced) hepatoblastomas; and 3) annotation factors P and V. The combination of pathologic findings and surgical records served as the reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Sensitivity, specificity, Fleiss kappa test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sensitivity and specificity ranges for discriminating advanced from non\u2010advanced hepatoblastomas were 73.3%\u201380.0% and 80.0%\u201390.0%, respectively. For annotation factor P, they were 66.7%\u2013100.0% and 90.6%, respectively. For factor V, they were 75.0% and 67.7%\u201383.9%, respectively. There was excellent, substantial, and moderate agreement on POSTTEXT staging (Fleiss kappa\u2009=\u20090.82), factors P (Fleiss kappa\u2009=\u20090.64), and factors V (Fleiss kappa\u2009=\u20090.60), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>MR POSTTEXT provides reliable discrimination between advanced and non\u2010advanced tumors, and MR has moderate to excellent specificity at identifying portal venous and hepatic venous\/IVC involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence Level<\/jats:title><jats:p>3<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy<\/jats:title><jats:p>Stage 3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28848","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T02:13:22Z","timestamp":1686104002000},"page":"1034-1042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pediatric Hepatoblastoma After Neoadjuvant Chemotherapy: Diagnostic Performance of <scp>MR<\/scp> in Staging <scp>POSTTEXT<\/scp> and Vascular Involvement"],"prefix":"10.1002","volume":"59","author":[{"given":"Xu Hua","family":"Gong","sequence":"first","affiliation":[{"name":"Radiology Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Xuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Liver Surgery Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Guo","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Radiology Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Qi","family":"Yan","sequence":"additional","affiliation":[{"name":"Radiology 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