{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T16:17:18Z","timestamp":1783786638046,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LGF22H040003"],"award-info":[{"award-number":["LGF22H040003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The fetal neurodevelopmental microstructural alterations of intrauterine exposure to preeclampsia (PE) or gestational hypertension (GH) remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the differences in diffusion\u2010weighted imaging (DWI) of the fetal brain between normotensive pregnancies and PE\/GH pregnancies, with a focus on PE\/GH pregnancies with fetal growth restriction (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective matched case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>40 singleton pregnancies with PE\/GH complicated by FGR, and 3 paired control groups (PE\/GH without FGR, normotensive FGR, normotensive pregnancies) (28\u201338 gestational weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>DWI with single\u2010shot echo\u2010planar imaging at 1.5 Tesla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The apparent diffusion coefficient (ADC) values were calculated in the centrum semi\u2010ovale (CSO), parietal white matter (PWM), frontal white matter (FWM), occipital white matter (OWM), temporal white matter (TWM), basal ganglia, thalamus (THAL), pons, and cerebellar hemisphere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Student t test or Wilcoxon matched test was used to reveal the difference of ADC values among the investigated brain regions. A correlation between gestational age (GA) and ADC values was determined by linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with fetuses in PE\/GH without FGR and those with normotensive pregnancies, fetuses in the PE\/GH with FGR group had significantly lower average ADC measurements of supratentorial regions (1.65\u2009\u00b1\u20090.09 vs. 1.71\u2009\u00b1\u20090.10 10<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/sec; vs. 1.73\u2009\u00b1\u20090.11 10<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/sec, respectively). Regions of significantly decreased ADC values in the fetal brain included CSO, FWM, PWM, OWM, TWM and THAL in cases of PE\/GH with FGR. ADC values from supratentorial regions in PE\/GH pregnancies were not significantly correlated with GA (<jats:italic>P<\/jats:italic>\u2009=\u20090.12, 0.26); however, this trend was statistically significant in the normotensive groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>ADC values may indicate fetal brain developmental alterations in PE\/GH with FGR fetuses but more microscopic and morphological studies are necessary to provide additional evidence to offer a different interpretation of this trend in fetal brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4<\/jats:p><\/jats:sec><jats:sec><jats:title>Technical Efficacy Stage<\/jats:title><jats:p>3<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.28861","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T18:04:18Z","timestamp":1686765858000},"page":"1384-1393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diffusion\u2010Weighted <scp>MRI<\/scp> of the Fetal Brain in Fetal Growth Restriction With Maternal Preeclampsia or Gestational Hypertension"],"prefix":"10.1002","volume":"59","author":[{"given":"Weizeng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology Women's Hospital School of Medicine Zhejiang University  Hangzhou 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